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- W2051266587 abstract "Summary Intravenous injection of the α‐adrenergic receptors agonist xylazine (0.3 mg/kg b. w.) produced hyperglycaemia with its peak (110 mg/100 ml) 30 min later in sheep. This hyperglycaemia was statistically significant for 3 hours. When xylazine was administered after pretreatment of the animals with either the α 1 ‐adrenergic receptors blocker prazosin (0.5 mg/kg i. v.) or the α 2 ‐blocker yohimbine (0.5 mg/kg i. v.) a hyperglycaemia was also produced but in the case of prazosin its peak did not exceed 95 mg/100 ml, and in the case of yohimbine it was only 70 mg/100 ml (control value 55 mg/100 ml). When animals were pretreated with either yohimbine plus prazosin or the α 1 ‐ and α 2 ‐blocker tolazoline (3 mg/kg i.v.) the hyperglycaemic effect of xylazine was inhibited. These results suggest that, in the regulation of blood glucose levels by the α‐adrenergic receptors, the α 2 play the main role, while the α 1 are also involved. Zusammenfassung Untersuchungen zur Rolle der α‐adrenergen Rezeptoren bei der Blutglucose‐Regulation bei Schafen: Die intravenöse Injektion des α‐Agonisten Xylazin (0,3 mg/kg KG) führte bei Schafen zu einer Hyperglykämie, die nach 30 min am ausgeprägtesten war (110 mg/100 ml) und 3 Stunden lang signifikant war. Bei Verabreichung von Xylazin nach Vorbehandlung der Tiere mit dem α 1 ‐Blocker Prazosin (0,5 mg/kg i. v.) oder dem α 2 ‐Blocker Yohimbin (0,5 mg/kg i. v.) trat ebenfalls eine Hyperglykämie auf, jedoch war der Blutglucose‐Peak im Fall von Prazosin nicht höher als 95 mg/100 ml, im Fall von Yohimbin sogar nur 70 mg/100 ml (Kontrollwert: 55 mg/100 ml). Wurden die Tiere entweder mit Yohimbin und Prazosin oder dem α 1 ‐ und α 2 ‐Blocker Tolazolin (3 mg/kg i. v.) vorbehandelt, so wurde der hyperglykämische Effekt von Xylazin unterdrückt. Diese Ergebnisse deuten darauf hin, daß bei der Regulation des Blutzuckerspiegels durch α‐adrenerge Rezeptoren die α 2 ‐Rezeptoren die Hauptrolle spielen, die α 1 ‐Rezeptoren aber ebenfalls beteiligt sind." @default.
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- W2051266587 date "1987-02-12" @default.
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- W2051266587 title "Xylazine-Induced Hyperglycaemia and α-Adrenergic Receptors in Sheep" @default.
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- W2051266587 doi "https://doi.org/10.1111/j.1439-0442.1987.tb00255.x" @default.
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