FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051267026> ?p ?o ?g. }

• W2051267026 endingPage "643" @default.
• W2051267026 startingPage "637" @default.
• W2051267026 abstract "The purpose of this study is to introduce a technical detail on a transplantation model for in vivo evaluation of microcirculatory changes during the acute phase of allograft rejection. The cremaster muscle is incorporated and transplanted along with the hind limb to detect and study ischemia/reperfusion injury and the acute phase of allograft rejection in rats. Thirty-six animals were studied in three experimental groups of 12 animals each. Each group was divided into subgroups and microcirculatory measurements were taken at two different time periods: 24 and 72 hours. In the ischemic control group (N = 12), cremaster muscles were denervated, prepared as a tube flap, and submitted to the same interval of ischemia as the other groups but without transplantation. In the isograft group (N = 12), rat hind limb-cremaster grafts were transplanted between genetically identical Lewis rats (RT11). In the allograft group (N = 12), 12 transplantations were performed across a major histocompatibility barrier between Lewis Brown-Norway (RT-11+/-n) and Lewis (RT 11) rats. The diameters of first-, second-, and third-order arterioles and venules; red blood cell velocities; and functional capillary density were recorded at 24 and 72 hours after transplantation. Daily follow-up observations were continued until 3 days after the first clinical signs of graft rejection. The mean number of perfused capillaries in the two transplantation groups was significantly lower than in the control group at both 24 hours and 72 hours (p < 0.05). Those results were as follows: 8.2 +/- 2.1 at 24 hours, 7.7 +/- 0.85 at 72 hours in the ischemic control group; 5.4 +/- 0.9 at 24 hours, 6 +/- 0.6 at 72 hours in the isograft group; and 5 +/- 0.9 at 24 hours, 5.5 +/- 0.3 at 72 hours in the allograft group. Red blood cell velocities and vessel diameters in the main arteries were also decreased in transplant groups at 24 hours (p < 0.05) but returned to normal 72 hours after the operation (p > 0.05). The composite rat hind limb-cremaster model presented in this study introduces a reproducible in vivo approach to monitor the differences in microcirculatory hemodynamics of ischemia/reperfusion injury and acute graft rejection. The model allows the study of the timing, sequence, and correlation between clinical and hemodynamic signs during the acute phase of allograft rejection." @default.
• W2051267026 created "2016-06-24" @default.
• W2051267026 creator A5031004780 @default.
• W2051267026 creator A5043928503 @default.
• W2051267026 creator A5060595502 @default.
• W2051267026 creator A5062727443 @default.
• W2051267026 date "2000-06-01" @default.
• W2051267026 modified "2023-09-27" @default.
• W2051267026 title "Microcirculatory Window for Early Detection of Allograft Rejection" @default.
• W2051267026 doi "https://doi.org/10.1097/00000637-200044060-00010" @default.
• W2051267026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10884081" @default.
• W2051267026 hasPublicationYear "2000" @default.
• W2051267026 type Work @default.
• W2051267026 sameAs 2051267026 @default.
• W2051267026 citedByCount "11" @default.
• W2051267026 countsByYear W20512670262014 @default.
• W2051267026 countsByYear W20512670262016 @default.
• W2051267026 countsByYear W20512670262018 @default.
• W2051267026 countsByYear W20512670262020 @default.
• W2051267026 crossrefType "journal-article" @default.
• W2051267026 hasAuthorship W2051267026A5031004780 @default.
• W2051267026 hasAuthorship W2051267026A5043928503 @default.
• W2051267026 hasAuthorship W2051267026A5060595502 @default.
• W2051267026 hasAuthorship W2051267026A5062727443 @default.
• W2051267026 hasConcept C105702510 @default.
• W2051267026 hasConcept C126322002 @default.
• W2051267026 hasConcept C12722491 @default.
• W2051267026 hasConcept C141071460 @default.
• W2051267026 hasConcept C2776354463 @default.
• W2051267026 hasConcept C2778252389 @default.
• W2051267026 hasConcept C2780114680 @default.
• W2051267026 hasConcept C2911091166 @default.
• W2051267026 hasConcept C51738704 @default.
• W2051267026 hasConcept C541997718 @default.
• W2051267026 hasConcept C71924100 @default.
• W2051267026 hasConceptScore W2051267026C105702510 @default.
• W2051267026 hasConceptScore W2051267026C126322002 @default.
• W2051267026 hasConceptScore W2051267026C12722491 @default.
• W2051267026 hasConceptScore W2051267026C141071460 @default.
• W2051267026 hasConceptScore W2051267026C2776354463 @default.
• W2051267026 hasConceptScore W2051267026C2778252389 @default.
• W2051267026 hasConceptScore W2051267026C2780114680 @default.
• W2051267026 hasConceptScore W2051267026C2911091166 @default.
• W2051267026 hasConceptScore W2051267026C51738704 @default.
• W2051267026 hasConceptScore W2051267026C541997718 @default.
• W2051267026 hasConceptScore W2051267026C71924100 @default.
• W2051267026 hasIssue "6" @default.
• W2051267026 hasLocation W20512670261 @default.
• W2051267026 hasLocation W20512670262 @default.
• W2051267026 hasOpenAccess W2051267026 @default.
• W2051267026 hasPrimaryLocation W20512670261 @default.
• W2051267026 hasRelatedWork W2014193194 @default.
• W2051267026 hasRelatedWork W2018762413 @default.
• W2051267026 hasRelatedWork W2046282509 @default.
• W2051267026 hasRelatedWork W2053258763 @default.
• W2051267026 hasRelatedWork W2079756336 @default.
• W2051267026 hasRelatedWork W2140733131 @default.
• W2051267026 hasRelatedWork W2414023712 @default.
• W2051267026 hasRelatedWork W2414461013 @default.
• W2051267026 hasRelatedWork W4242011101 @default.
• W2051267026 hasRelatedWork W3022533335 @default.
• W2051267026 hasVolume "44" @default.
• W2051267026 isParatext "false" @default.
• W2051267026 isRetracted "false" @default.
• W2051267026 magId "2051267026" @default.
• W2051267026 workType "article" @default.