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• W2051268137 abstract "In utero smoke exposure has been shown to have detrimental effects on lung function and to be associated with persistent wheezing and asthma in children. One potential mechanism of IUS effects could be alterations in DNA methylation, which may have life-long implications. The goal of this study was to examine the association between DNA methylation and nicotine exposure in fetal lung and placental tissue in early development; nicotine exposure in this analysis represents a likely surrogate for in-utero smoke. We performed an epigenome-wide analysis of DNA methylation in fetal lung tissue (n = 85, 41 smoke exposed (48%), 44 controls) and the corresponding placental tissue samples (n = 80, 39 smoke exposed (49%), 41 controls) using the Illumina HumanMethylation450 BeadChip array. Differential methylation analyses were conducted to evaluate the variation associated with nicotine exposure. The most significant CpG sites in the fetal lung analysis mapped to the PKP3 (P = 2.94 × 10(-03)), ANKRD33B (P = 3.12 × 10(-03)), CNTD2 (P = 4.9 × 10(-03)) and DPP10 (P = 5.43 × 10(-03)) genes. In the placental methylome, the most significant CpG sites mapped to the GTF2H2C and GTF2H2D genes (P = 2.87 × 10(-06) - 3.48 × 10(-05)). One hundred and one unique CpG sites with P-values < 0.05 were concordant between lung and placental tissue analyses. Gene Set Enrichment Analysis demonstrated enrichment of specific disorders, such as asthma and immune disorders. Our findings demonstrate an association between in utero nicotine exposure and variable DNA methylation in fetal lung and placental tissues, suggesting a role for DNA methylation variation in the fetal origins of chronic diseases." @default.
• W2051268137 created "2016-06-24" @default.
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• W2051268137 date "2014-11-02" @default.
• W2051268137 modified "2023-10-16" @default.
• W2051268137 title "Fetal lung and placental methylation is associated with in utero nicotine exposure" @default.
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• W2051268137 cites W1965180581 @default.
• W2051268137 cites W1967540420 @default.
• W2051268137 cites W1970876784 @default.
• W2051268137 cites W1971217505 @default.
• W2051268137 cites W1986684176 @default.
• W2051268137 cites W1989989220 @default.
• W2051268137 cites W1991254677 @default.
• W2051268137 cites W1991723608 @default.
• W2051268137 cites W1996169104 @default.
• W2051268137 cites W1997824331 @default.
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• W2051268137 cites W2006780497 @default.
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• W2051268137 cites W2020247675 @default.
• W2051268137 cites W2020776064 @default.
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• W2051268137 cites W2054006501 @default.
• W2051268137 cites W2066748935 @default.
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• W2051268137 doi "https://doi.org/10.4161/15592294.2014.971593" @default.
• W2051268137 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4623268" @default.
• W2051268137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25482056" @default.
• W2051268137 hasPublicationYear "2014" @default.
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