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• W2051268587 abstract "Thrombin is a multifaceted protein with a wide range of functions. Walter Seegers, a pioneer in thrombin work, referred to it as “the living enzyme of my blood.” 1 Seegers WH Thomas WR Landaburu RH et al. Prothrombin: living enzyme of my blood. Rec Chem Prog. 1960; 21: 1-18 Google Scholar The central importance of thrombin in biology, physiology, and pathology is clearly shown by studies conducted with genetically homogenous mice made deficient in components of coagulant pathways essential to thrombin generation and its regulation. Transgenic mice deficient in tissue factor, 2 Toomey JR Kratzer KE Lasky NM et al. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood. 1996; 88: 1583-1587 Crossref PubMed Google Scholar factor VII, 3 Rosen ED Chan JC Idusogie E et al. Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature. 1997; 390: 290-294 Crossref PubMed Scopus (184) Google Scholar tissue factor pathway inhibitor, 4 Huang ZF Higuchi D Lasky N et al. Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood. 1997; 90: 944-951 Crossref PubMed Google Scholar factor X, 5 Dewerchin M Liang Z Moons L et al. Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost. 2000; 83: 185-190 Crossref PubMed Scopus (136) Google Scholar factor V, 6 Cui J O'Shea KS Purkayastha A et al. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature. 1996; 384: 66-68 Crossref PubMed Scopus (206) Google Scholar prothrombin, 7 Sun WY Witte DP Degen JL et al. Prothrombin deficiency results in embryonic and neonatal lethality in mice. Proc Natl Acad Sci U S A. 1998; 95: 7597-7602 Crossref PubMed Scopus (204) Google Scholar and protein C 8 Jalbert LR Rosen ED Moons L et al. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest. 1998; 102: 1481-1488 Crossref PubMed Scopus (139) Google Scholar die in utero or shortly after birth. In contrast, in the outbred human population, deficiencies of coagulation components, essential in mice, yield consequences ranging from mild-to-severe pathology. These observations underscore the complexity of managing the outbred human population with respect to interventions for both thrombosis and hemostasis." @default.
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• W2051268587 date "2003-09-01" @default.
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• W2051268587 title "Thrombin" @default.
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• W2051268587 doi "https://doi.org/10.1378/chest.124.3_suppl.1s" @default.
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