FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051268732> ?p ?o ?g. }

• W2051268732 endingPage "369" @default.
• W2051268732 startingPage "363" @default.
• W2051268732 abstract "We describe herein the structural optimization of new piperamide analogues, designed from two natural prototypes, piperine 1 and piperdardine 2, obtained from Piper tuberculatum Jacq. (Piperaceae). Molecular modeling studies using semiempirical AM1 method were made in order to establish rational modifications to optimize them by molecular simplification. The targeted compounds (10) and (11) were respectively obtained using benzaldehyde (12) and para-anisaldehyde (13) as starting materials. 1H NMR spectra showed that the target compounds were diastereoselectively obtained as the (E)-isomer, the same geometry of the natural prototypes. These new synthetic amides presented significant hypotensive effects in cardiovascular essays using in vivo methodologies. Compound 11 (N-[5-(4'-methoxyphenyl)-2(E)-pentenoyl]thiomorpholine) showed a potency 10,000 times greater than its prototype 5, evidencing an optimization of the molecular architecture for this class of hypotensive drug candidates." @default.
• W2051268732 created "2016-06-24" @default.
• W2051268732 creator A5012269253 @default.
• W2051268732 creator A5038019453 @default.
• W2051268732 creator A5039582274 @default.
• W2051268732 creator A5041488922 @default.
• W2051268732 creator A5076822552 @default.
• W2051268732 creator A5086599258 @default.
• W2051268732 date "2004-12-01" @default.
• W2051268732 modified "2023-10-18" @default.
• W2051268732 title "New optimized piperamide analogues with potent in vivo hypotensive properties" @default.
• W2051268732 cites W1967159419 @default.
• W2051268732 cites W1969031304 @default.
• W2051268732 cites W1991314707 @default.
• W2051268732 cites W1997013261 @default.
• W2051268732 cites W2029162289 @default.
• W2051268732 cites W2085997538 @default.
• W2051268732 cites W2092706185 @default.
• W2051268732 cites W2132528830 @default.
• W2051268732 cites W2950653783 @default.
• W2051268732 cites W4296550727 @default.
• W2051268732 doi "https://doi.org/10.1016/j.ejps.2004.08.011" @default.
• W2051268732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15567289" @default.
• W2051268732 hasPublicationYear "2004" @default.
• W2051268732 type Work @default.
• W2051268732 sameAs 2051268732 @default.
• W2051268732 citedByCount "27" @default.
• W2051268732 countsByYear W20512687322013 @default.
• W2051268732 countsByYear W20512687322014 @default.
• W2051268732 countsByYear W20512687322015 @default.
• W2051268732 countsByYear W20512687322016 @default.
• W2051268732 countsByYear W20512687322019 @default.
• W2051268732 countsByYear W20512687322020 @default.
• W2051268732 countsByYear W20512687322021 @default.
• W2051268732 crossrefType "journal-article" @default.
• W2051268732 hasAuthorship W2051268732A5012269253 @default.
• W2051268732 hasAuthorship W2051268732A5038019453 @default.
• W2051268732 hasAuthorship W2051268732A5039582274 @default.
• W2051268732 hasAuthorship W2051268732A5041488922 @default.
• W2051268732 hasAuthorship W2051268732A5076822552 @default.
• W2051268732 hasAuthorship W2051268732A5086599258 @default.
• W2051268732 hasConcept C103319777 @default.
• W2051268732 hasConcept C150903083 @default.
• W2051268732 hasConcept C161790260 @default.
• W2051268732 hasConcept C178790620 @default.
• W2051268732 hasConcept C178910836 @default.
• W2051268732 hasConcept C185592680 @default.
• W2051268732 hasConcept C202751555 @default.
• W2051268732 hasConcept C207001950 @default.
• W2051268732 hasConcept C21951064 @default.
• W2051268732 hasConcept C2777155639 @default.
• W2051268732 hasConcept C2777185600 @default.
• W2051268732 hasConcept C2779692420 @default.
• W2051268732 hasConcept C2780133158 @default.
• W2051268732 hasConcept C55493867 @default.
• W2051268732 hasConcept C556039675 @default.
• W2051268732 hasConcept C57992300 @default.
• W2051268732 hasConcept C71240020 @default.
• W2051268732 hasConcept C71924100 @default.
• W2051268732 hasConcept C86803240 @default.
• W2051268732 hasConceptScore W2051268732C103319777 @default.
• W2051268732 hasConceptScore W2051268732C150903083 @default.
• W2051268732 hasConceptScore W2051268732C161790260 @default.
• W2051268732 hasConceptScore W2051268732C178790620 @default.
• W2051268732 hasConceptScore W2051268732C178910836 @default.
• W2051268732 hasConceptScore W2051268732C185592680 @default.
• W2051268732 hasConceptScore W2051268732C202751555 @default.
• W2051268732 hasConceptScore W2051268732C207001950 @default.
• W2051268732 hasConceptScore W2051268732C21951064 @default.
• W2051268732 hasConceptScore W2051268732C2777155639 @default.
• W2051268732 hasConceptScore W2051268732C2777185600 @default.
• W2051268732 hasConceptScore W2051268732C2779692420 @default.
• W2051268732 hasConceptScore W2051268732C2780133158 @default.
• W2051268732 hasConceptScore W2051268732C55493867 @default.
• W2051268732 hasConceptScore W2051268732C556039675 @default.
• W2051268732 hasConceptScore W2051268732C57992300 @default.
• W2051268732 hasConceptScore W2051268732C71240020 @default.
• W2051268732 hasConceptScore W2051268732C71924100 @default.
• W2051268732 hasConceptScore W2051268732C86803240 @default.
• W2051268732 hasIssue "4-5" @default.
• W2051268732 hasLocation W20512687321 @default.
• W2051268732 hasLocation W20512687322 @default.
• W2051268732 hasOpenAccess W2051268732 @default.
• W2051268732 hasPrimaryLocation W20512687321 @default.
• W2051268732 hasRelatedWork W1965155339 @default.
• W2051268732 hasRelatedWork W2043621605 @default.
• W2051268732 hasRelatedWork W2051268732 @default.
• W2051268732 hasRelatedWork W2067018229 @default.
• W2051268732 hasRelatedWork W2149057806 @default.
• W2051268732 hasRelatedWork W2474101086 @default.
• W2051268732 hasRelatedWork W2949718299 @default.
• W2051268732 hasRelatedWork W2974654055 @default.
• W2051268732 hasRelatedWork W2983757964 @default.
• W2051268732 hasRelatedWork W3183762725 @default.
• W2051268732 hasVolume "23" @default.
• W2051268732 isParatext "false" @default.
• W2051268732 isRetracted "false" @default.
• W2051268732 magId "2051268732" @default.

• next