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- W2051268743 endingPage "543" @default.
- W2051268743 startingPage "529" @default.
- W2051268743 abstract "Alzheimer’s disease (AD) is the 3rd most costly disease and the leading cause of dementia. It can linger for many years, but ultimately is fatal, the 6th leading cause of death. Alzheimer’s disease (AD) is fatal and affected individuals can sometimes linger many years. Current treatments are palliative and transient, not disease modifying. This article reviews progress in the search to identify the primary AD-causing toxins. We summarize the shift from an initial focus on amyloid plaques to the contemporary concept that AD memory failure is caused by small soluble oligomers of the Aβ peptide, toxins that target and disrupt particular synapses. Evidence is presented that links Aβ oligomers to pathogenesis in animal models and humans, with reference to seminal discoveries from cell biology and new ideas concerning pathogenic mechanisms, including relationships to diabetes and Fragile X. These findings have established the oligomer hypothesis as a new molecular basis for the cause, diagnosis, and treatment of AD." @default.
- W2051268743 created "2016-06-24" @default.
- W2051268743 creator A5054687151 @default.
- W2051268743 creator A5070851422 @default.
- W2051268743 date "2011-11-01" @default.
- W2051268743 modified "2023-10-03" @default.
- W2051268743 title "The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease" @default.
- W2051268743 cites W120784412 @default.
- W2051268743 cites W1500301897 @default.
- W2051268743 cites W150222691 @default.
- W2051268743 cites W1511127813 @default.
- W2051268743 cites W1522472244 @default.
- W2051268743 cites W1527910050 @default.
- W2051268743 cites W1543788907 @default.
- W2051268743 cites W1546369396 @default.
- W2051268743 cites W1566564316 @default.
- W2051268743 cites W1570302318 @default.
- W2051268743 cites W1575733811 @default.
- W2051268743 cites W157753509 @default.
- W2051268743 cites W1584774790 @default.
- W2051268743 cites W1584834830 @default.
- W2051268743 cites W1605971438 @default.
- W2051268743 cites W1616122655 @default.
- W2051268743 cites W1637989849 @default.
- W2051268743 cites W1677883125 @default.
- W2051268743 cites W1705725530 @default.
- W2051268743 cites W1710226705 @default.
- W2051268743 cites W1718410121 @default.
- W2051268743 cites W17230872 @default.
- W2051268743 cites W1802455527 @default.
- W2051268743 cites W1819107323 @default.
- W2051268743 cites W1857351893 @default.
- W2051268743 cites W1864791610 @default.
- W2051268743 cites W1913141297 @default.
- W2051268743 cites W1951083945 @default.
- W2051268743 cites W1963640549 @default.
- W2051268743 cites W1963687105 @default.
- W2051268743 cites W1964741226 @default.
- W2051268743 cites W1967464880 @default.
- W2051268743 cites W1967564647 @default.
- W2051268743 cites W1968530575 @default.
- W2051268743 cites W1968973248 @default.
- W2051268743 cites W1969880746 @default.
- W2051268743 cites W1970164987 @default.
- W2051268743 cites W1970874743 @default.
- W2051268743 cites W1971116512 @default.
- W2051268743 cites W1972609075 @default.
- W2051268743 cites W1974823287 @default.
- W2051268743 cites W1976568654 @default.
- W2051268743 cites W1976599886 @default.
- W2051268743 cites W1976602187 @default.
- W2051268743 cites W1978554758 @default.
- W2051268743 cites W1979008330 @default.
- W2051268743 cites W1980750700 @default.
- W2051268743 cites W1981205792 @default.
- W2051268743 cites W1981570625 @default.
- W2051268743 cites W1981698244 @default.
- W2051268743 cites W1982373527 @default.
- W2051268743 cites W1982810155 @default.
- W2051268743 cites W1984924722 @default.
- W2051268743 cites W1985323612 @default.
- W2051268743 cites W1986635066 @default.
- W2051268743 cites W1986686062 @default.
- W2051268743 cites W1987416014 @default.
- W2051268743 cites W1987922097 @default.
- W2051268743 cites W1989948422 @default.
- W2051268743 cites W1990752558 @default.
- W2051268743 cites W1991241547 @default.
- W2051268743 cites W1991988242 @default.
- W2051268743 cites W1992674527 @default.
- W2051268743 cites W1993019632 @default.
- W2051268743 cites W1993274829 @default.
- W2051268743 cites W1993465897 @default.
- W2051268743 cites W1993712369 @default.
- W2051268743 cites W1993759415 @default.
- W2051268743 cites W1994497989 @default.
- W2051268743 cites W1995491925 @default.
- W2051268743 cites W1995580860 @default.
- W2051268743 cites W1995648866 @default.
- W2051268743 cites W1996132904 @default.
- W2051268743 cites W1998553787 @default.
- W2051268743 cites W1998751065 @default.
- W2051268743 cites W1999486225 @default.
- W2051268743 cites W1999514420 @default.
- W2051268743 cites W2001688761 @default.
- W2051268743 cites W2001900724 @default.
- W2051268743 cites W2002280328 @default.
- W2051268743 cites W2002364516 @default.
- W2051268743 cites W2002617729 @default.
- W2051268743 cites W2003655335 @default.
- W2051268743 cites W2004968757 @default.
- W2051268743 cites W2007495000 @default.
- W2051268743 cites W2007849320 @default.
- W2051268743 cites W2008337884 @default.
- W2051268743 cites W2009174342 @default.
- W2051268743 cites W2009755157 @default.
- W2051268743 cites W2010037905 @default.
- W2051268743 cites W2011335492 @default.