FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051268888> ?p ?o ?g. }

• W2051268888 endingPage "545" @default.
• W2051268888 startingPage "535" @default.
• W2051268888 abstract "Seven different forms of the enzyme COMT (catechol O-methyltransferase) were found in isolated rat hepatocytes by two-dimensional gel electrophoresis and immunoblotting: five small variants (S-COMT) and two large variants (L-COMT). The identities of these COMT forms were verified by tryptic fingerprinting using MALDI–TOF (matrix-assisted laser-desorption ionization–time-of-flight) MS, and by amino acid sequencing using ESI–IT–MS/MS (electrospray ionization with ion-trap tandem MS). Analysis of tissue distributions showed that the S-COMT forms were highly expressed in liver and kidney, whereas L-COMT was expressed more strongly in other tissues. Both of the L-COMT forms were found in all of the tissues examined except the heart, which expressed only the most acidic form, and the kidney, which expressed only the most basic form. Subcellular fractionation revealed the presence of both S-COMT and L-COMT in soluble, as well as sedimentable, fractions, suggesting that they should be classified by size rather than (as previously) by localization. Several of the S-COMT forms were N-acetylated, and the two most acidic forms were found to be phosphorylated at Ser260. One of the latter was unique to liver cells; the other was also found in kidney, brain and thymus. Among the non-phosphorylated S-COMT forms, one was ubiquitous, one was found in testis and liver, and a third was found in liver, kidney and thymus. No other phosphorylated sites were found, suggesting that the pI differences distinguishing between the various COMT forms are due to some as yet unidentified structural modification(s)." @default.
• W2051268888 created "2016-06-24" @default.
• W2051268888 creator A5029334916 @default.
• W2051268888 creator A5087977447 @default.
• W2051268888 date "2008-12-23" @default.
• W2051268888 modified "2023-10-16" @default.
• W2051268888 title "Phosphorylated and non-phosphorylated forms of catechol <i>O</i>-methyltransferase in rat liver, brain and other tissues" @default.
• W2051268888 cites W1490154674 @default.
• W2051268888 cites W1543624067 @default.
• W2051268888 cites W1576680346 @default.
• W2051268888 cites W1967021779 @default.
• W2051268888 cites W1970128454 @default.
• W2051268888 cites W1970422172 @default.
• W2051268888 cites W1971629352 @default.
• W2051268888 cites W1977767269 @default.
• W2051268888 cites W1986059489 @default.
• W2051268888 cites W1988023403 @default.
• W2051268888 cites W1996395058 @default.
• W2051268888 cites W1998385675 @default.
• W2051268888 cites W2002609852 @default.
• W2051268888 cites W2006975403 @default.
• W2051268888 cites W2008288225 @default.
• W2051268888 cites W2009165358 @default.
• W2051268888 cites W2025642899 @default.
• W2051268888 cites W2027043097 @default.
• W2051268888 cites W2029593635 @default.
• W2051268888 cites W2034763673 @default.
• W2051268888 cites W2038163496 @default.
• W2051268888 cites W2046515690 @default.
• W2051268888 cites W2048333869 @default.
• W2051268888 cites W2048666997 @default.
• W2051268888 cites W2049880669 @default.
• W2051268888 cites W2069264937 @default.
• W2051268888 cites W2087719707 @default.
• W2051268888 cites W2090339115 @default.
• W2051268888 cites W2097965918 @default.
• W2051268888 cites W2100040984 @default.
• W2051268888 cites W2100837269 @default.
• W2051268888 cites W2102347727 @default.
• W2051268888 cites W2113121748 @default.
• W2051268888 cites W2127401167 @default.
• W2051268888 cites W2129488724 @default.
• W2051268888 cites W2146977154 @default.
• W2051268888 cites W2155330019 @default.
• W2051268888 cites W245658158 @default.
• W2051268888 cites W4232534952 @default.
• W2051268888 cites W4293247451 @default.
• W2051268888 cites W55624665 @default.
• W2051268888 cites W2055552942 @default.
• W2051268888 doi "https://doi.org/10.1042/bj20081284" @default.
• W2051268888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18831714" @default.
• W2051268888 hasPublicationYear "2008" @default.
• W2051268888 type Work @default.
• W2051268888 sameAs 2051268888 @default.
• W2051268888 citedByCount "17" @default.
• W2051268888 countsByYear W20512688882012 @default.
• W2051268888 countsByYear W20512688882015 @default.
• W2051268888 countsByYear W20512688882016 @default.
• W2051268888 countsByYear W20512688882017 @default.
• W2051268888 countsByYear W20512688882019 @default.
• W2051268888 crossrefType "journal-article" @default.
• W2051268888 hasAuthorship W2051268888A5029334916 @default.
• W2051268888 hasAuthorship W2051268888A5087977447 @default.
• W2051268888 hasConcept C104317684 @default.
• W2051268888 hasConcept C11960822 @default.
• W2051268888 hasConcept C134018914 @default.
• W2051268888 hasConcept C135763542 @default.
• W2051268888 hasConcept C153911025 @default.
• W2051268888 hasConcept C181199279 @default.
• W2051268888 hasConcept C185361966 @default.
• W2051268888 hasConcept C185592680 @default.
• W2051268888 hasConcept C27239569 @default.
• W2051268888 hasConcept C2780091579 @default.
• W2051268888 hasConcept C33288867 @default.
• W2051268888 hasConcept C552990157 @default.
• W2051268888 hasConcept C55493867 @default.
• W2051268888 hasConcept C86803240 @default.
• W2051268888 hasConcept C91965660 @default.
• W2051268888 hasConceptScore W2051268888C104317684 @default.
• W2051268888 hasConceptScore W2051268888C11960822 @default.
• W2051268888 hasConceptScore W2051268888C134018914 @default.
• W2051268888 hasConceptScore W2051268888C135763542 @default.
• W2051268888 hasConceptScore W2051268888C153911025 @default.
• W2051268888 hasConceptScore W2051268888C181199279 @default.
• W2051268888 hasConceptScore W2051268888C185361966 @default.
• W2051268888 hasConceptScore W2051268888C185592680 @default.
• W2051268888 hasConceptScore W2051268888C27239569 @default.
• W2051268888 hasConceptScore W2051268888C2780091579 @default.
• W2051268888 hasConceptScore W2051268888C33288867 @default.
• W2051268888 hasConceptScore W2051268888C552990157 @default.
• W2051268888 hasConceptScore W2051268888C55493867 @default.
• W2051268888 hasConceptScore W2051268888C86803240 @default.
• W2051268888 hasConceptScore W2051268888C91965660 @default.
• W2051268888 hasIssue "2" @default.
• W2051268888 hasLocation W20512688881 @default.
• W2051268888 hasLocation W20512688882 @default.
• W2051268888 hasOpenAccess W2051268888 @default.
• W2051268888 hasPrimaryLocation W20512688881 @default.

• next