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- W2051269506 abstract "Potential tigecycline-Enterobacteriaceae susceptibility breakpoints were evaluated using 2 approaches, which differed in the nature of the probabilities assessed by MIC value. Using a previously derived tigecycline population pharmacokinetic model and Monte Carlo simulation, a probability density function of steady-state area under the concentration–time curve for 24 h (AUCSS(0-24)) values for 9999 patients was generated. AUCSS(0-24) values were divided by clinically relevant fixed MIC values to derive AUCSS(0-24)/MIC ratios, which were used to calculate the clinical response expectation by MIC value based upon a logistic regression model for efficacy (1st approach). For the 2nd approach, the probability of pharmacokinetic–pharmacodynamic (PK-PD) target attainment was calculated as the proportion of patients with AUCSS(0-24)/MIC ratios greater than the threshold value of 6.96, the PK-PD target associated with optimal clinical response. Probabilities of clinical response and PK-PD target attainment were poorly correlated at MIC values >0.25 mg/L. For instance, the median probability of clinical success was 0.76, whereas the probability of PK-PD target attainment was 0.27 at an MIC value of 1 mg/L, suggesting that the probability of PK-PD target attainment metrics underestimates the clinical performance of tigecycline at higher MIC values." @default.
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- W2051269506 date "2009-01-01" @default.
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- W2051269506 title "Use of a clinically derived exposure–response relationship to evaluate potential tigecycline-Enterobacteriaceae susceptibility breakpoints" @default.
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- W2051269506 doi "https://doi.org/10.1016/j.diagmicrobio.2008.09.014" @default.
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