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- W2051269651 endingPage "7" @default.
- W2051269651 startingPage "1" @default.
- W2051269651 abstract "Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV). Extensive research over the past decades has unveiled the important role of cccDNA in the natural history and antiviral treatment of chronic HBV infection. cccDNA can persist in patients recovering from acute HBV infection for decades. This explains why HBV reactivation occasionally occurs in patients with resolved hepatitis B receiving intensive immunosuppressive agents. In addition, although advances in antiviral treatment dramatically improve the adverse outcomes of chronic hepatitis B (CHB), accumulating evidence demonstrates that current antiviral treatments alone, be they nucleos(t)ide analogs (NAs) or interferon (IFN), fail to cure most CHB patients because of the persistent cccDNA. NA suppresses HBV replication by directly inhibiting viral polymerase, while IFN enhances host immunity against HBV infection. Viral rebound often occurs after discontinuation of antiviral treatment. The loss of cccDNA can be induced by non-cytolytic destruction of cccDNA or immune-mediated killing of infected hepatocytes. It is known that NA has no direct effect on viral transcription or cccDNA stability. Therefore, the long half-life of hepatocytes leads to a very slow decline in cccDNA in patients under antiviral therapy. Novel antiviral agents targeting cccDNA or cccDNA-containing hepatocytes are thus required for curing chronic HBV infection." @default.
- W2051269651 created "2016-06-24" @default.
- W2051269651 creator A5003451116 @default.
- W2051269651 creator A5063550464 @default.
- W2051269651 date "2014-01-01" @default.
- W2051269651 modified "2023-10-18" @default.
- W2051269651 title "Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: molecular mechanisms and clinical significance" @default.
- W2051269651 cites W1496409007 @default.
- W2051269651 cites W1500215579 @default.
- W2051269651 cites W1676377504 @default.
- W2051269651 cites W178242959 @default.
- W2051269651 cites W1795594615 @default.
- W2051269651 cites W1817144267 @default.
- W2051269651 cites W1934998482 @default.
- W2051269651 cites W1965075846 @default.
- W2051269651 cites W1968184723 @default.
- W2051269651 cites W1969732006 @default.
- W2051269651 cites W1973866726 @default.
- W2051269651 cites W1974721186 @default.
- W2051269651 cites W1975550487 @default.
- W2051269651 cites W1979750575 @default.
- W2051269651 cites W1979792611 @default.
- W2051269651 cites W1979909270 @default.
- W2051269651 cites W1982255712 @default.
- W2051269651 cites W1987051472 @default.
- W2051269651 cites W1988062715 @default.
- W2051269651 cites W1988615815 @default.
- W2051269651 cites W1991592276 @default.
- W2051269651 cites W1992475294 @default.
- W2051269651 cites W1995085389 @default.
- W2051269651 cites W1996544788 @default.
- W2051269651 cites W1997047331 @default.
- W2051269651 cites W1998671948 @default.
- W2051269651 cites W2001927030 @default.
- W2051269651 cites W2002194637 @default.
- W2051269651 cites W2002897411 @default.
- W2051269651 cites W2002973116 @default.
- W2051269651 cites W2003422486 @default.
- W2051269651 cites W2003692477 @default.
- W2051269651 cites W2006048765 @default.
- W2051269651 cites W2007902841 @default.
- W2051269651 cites W2009744628 @default.
- W2051269651 cites W2011736290 @default.
- W2051269651 cites W2015763479 @default.
- W2051269651 cites W2016861292 @default.
- W2051269651 cites W2021297995 @default.
- W2051269651 cites W2022853819 @default.
- W2051269651 cites W2023378490 @default.
- W2051269651 cites W2024015543 @default.
- W2051269651 cites W2026510478 @default.
- W2051269651 cites W2031510386 @default.
- W2051269651 cites W2031579836 @default.
- W2051269651 cites W2032324413 @default.
- W2051269651 cites W2034440827 @default.
- W2051269651 cites W2035920453 @default.
- W2051269651 cites W2038992316 @default.
- W2051269651 cites W2039354155 @default.
- W2051269651 cites W2042638818 @default.
- W2051269651 cites W2043090634 @default.
- W2051269651 cites W2043987692 @default.
- W2051269651 cites W2047068182 @default.
- W2051269651 cites W2050571266 @default.
- W2051269651 cites W2050694322 @default.
- W2051269651 cites W2051173965 @default.
- W2051269651 cites W2054227142 @default.
- W2051269651 cites W2056132396 @default.
- W2051269651 cites W2056399135 @default.
- W2051269651 cites W2058751290 @default.
- W2051269651 cites W2059962010 @default.
- W2051269651 cites W2063295060 @default.
- W2051269651 cites W2074118280 @default.
- W2051269651 cites W2075595885 @default.
- W2051269651 cites W2076433001 @default.
- W2051269651 cites W2077172281 @default.
- W2051269651 cites W2078828237 @default.
- W2051269651 cites W2080034461 @default.
- W2051269651 cites W2084152099 @default.
- W2051269651 cites W2084686098 @default.
- W2051269651 cites W2088165891 @default.
- W2051269651 cites W2089153567 @default.
- W2051269651 cites W2089589904 @default.
- W2051269651 cites W2090973261 @default.
- W2051269651 cites W2096094255 @default.
- W2051269651 cites W2098458274 @default.
- W2051269651 cites W2098459535 @default.
- W2051269651 cites W2099708859 @default.
- W2051269651 cites W2100587714 @default.
- W2051269651 cites W2103458510 @default.
- W2051269651 cites W2104514309 @default.
- W2051269651 cites W2105853552 @default.
- W2051269651 cites W2107057287 @default.
- W2051269651 cites W2108226840 @default.
- W2051269651 cites W2112198869 @default.
- W2051269651 cites W2112908753 @default.
- W2051269651 cites W2115715165 @default.
- W2051269651 cites W2115819181 @default.
- W2051269651 cites W2117181252 @default.
- W2051269651 cites W2120426460 @default.