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- W2051270079 abstract "Intracisternal injection of blood in the rat induced an angiographically demonstrable biphasic cerebral vasospasm with a maximal acute spasm at 10 min and a maximal late spasm at 2 days after the subarachnoid hemorrhage. Systemic administration of 6-hydroxydopamine, which destroys catecholamine fibers in the circumventricular areas characterized by the absence of a blood–brain barrier, prevented the development of both the acute and the late spasm. Isolation or removal of one of the circumventricular organs, the pituitary, from the brain via a stalk transection or a hypophysectomy did not affect the degree of vasospasm. Lesion of the median eminence, another region without a blood–brain barrier, prevented the development of both types of spasm. The median eminence receives projections from the A 1 and A 2 nuclei in the medulla oblongata. It is suggested that the projections of these nuclei to the internal layer of the median eminence underlie the development of spasm." @default.
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- W2051270079 date "1986-12-01" @default.
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- W2051270079 title "Effect of Selective Lesions in the Hypothalamic—Pituitary Region on the Development of Cerebral Vasospasm following an Experimental Subarachnoid Hemorrhage in the Rat" @default.
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- W2051270079 doi "https://doi.org/10.1038/jcbfm.1986.120" @default.
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