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- W2051270689 abstract "Summary Seminal vesicles of anuran amphibian Discoglossus pictus were incubated in vitro with testosterone-4-14C. The following metabolites were isolated and identified: 5α-androstane-17β-ol-3-one (5α-DHT), 5α-androstane-3α,17β-diol,5α-androstane-3β,17β-diol and androstenedione. The intracellular distribution of 5α-reductase activity has been studied; aΔ4-3-ketosteroid 5α-oxydoreductase has been found in the nuclear fraction, in the microsomal fraction and in the cytosol fraction (200.000 × g supernatant during 60 minutes). No purification of the 5α-reductase could be achieved in any fraction. Approximatively one half of the total 5α-reductase activity was associated with the nuclei and about 30 p. cent with the supernatant fraction. The enzyme was shown to have a pH optimum of around 6,6 and a temperature optimum about 35°C. The 5α-reductase activity exhibited an absolute requirement for NADPH. The apparent Km values obtained were 1.4 × 10−5 M for NADPH and 0.4 × 10−6 M for testosterone." @default.
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- W2051270689 date "1973-10-01" @default.
- W2051270689 modified "2023-10-01" @default.
- W2051270689 title "Caractérisation partielle d'une Δ4-3-cetostéroïde-5α-oxydoréductase dans les vésicules séminales de l'amphibien anoure Discoglossus pictus" @default.
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- W2051270689 doi "https://doi.org/10.1016/s0300-9084(73)80167-1" @default.
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