Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051270707> ?p ?o ?g. }
- W2051270707 endingPage "F542" @default.
- W2051270707 startingPage "F535" @default.
- W2051270707 abstract "We tested whether luminal perfusion and pressurization induce an endothelial cytoplasmic Ca 2+ ([Ca 2+ ] CYT ) response in descending vasa recta (DVR). DVR isolated from the rat outer medulla were cannulated and subjected to free-flow microperfusion (5 nl/min); the onset of which increased [Ca 2+ ] CYT from a baseline of 76 ± 13 to 221 ± 65 nM. A graded increase in luminal pressure from 0 to 45 mmHg in stopped-flow experiments induced a parallel increase in [Ca 2+ ] CYT from a baseline of 74 ± 24 to 194 ± 33 nM at 45 mmHg, with a tendency for [Ca 2+ ] CYT to plateau at pressures >25 mmHg. The removal of extracellular Ca 2+ and blockade by either La 3+ (10 μM) or SKF-96365 (100 μM) eliminated the response. Luminal pressurization to 25 mmHg increased nitric oxide (NO) generation, a response blocked by NO synthase inhibition or removal of extracellular Ca 2+ . The NO generation was not affected by the superoxide dismutase mimetic tempol. We conclude that DVR endothelia are mechanosensitive and respond to luminal pressure by elevating [Ca 2+ ] CYT and generating NO. That response might augment medullary perfusion and saliuresis." @default.
- W2051270707 created "2016-06-24" @default.
- W2051270707 creator A5016230294 @default.
- W2051270707 creator A5021269788 @default.
- W2051270707 date "2004-09-01" @default.
- W2051270707 modified "2023-10-15" @default.
- W2051270707 title "Response of descending vasa recta to luminal pressure" @default.
- W2051270707 cites W149371867 @default.
- W2051270707 cites W1607892649 @default.
- W2051270707 cites W1733554135 @default.
- W2051270707 cites W1878233011 @default.
- W2051270707 cites W1930499844 @default.
- W2051270707 cites W1936770188 @default.
- W2051270707 cites W1974001927 @default.
- W2051270707 cites W1985093096 @default.
- W2051270707 cites W2005666104 @default.
- W2051270707 cites W2008790997 @default.
- W2051270707 cites W2009825870 @default.
- W2051270707 cites W2034804924 @default.
- W2051270707 cites W2035423155 @default.
- W2051270707 cites W2040664792 @default.
- W2051270707 cites W2040839194 @default.
- W2051270707 cites W2041430298 @default.
- W2051270707 cites W2043816861 @default.
- W2051270707 cites W2058248915 @default.
- W2051270707 cites W2071340957 @default.
- W2051270707 cites W2076677456 @default.
- W2051270707 cites W2087932834 @default.
- W2051270707 cites W2110795699 @default.
- W2051270707 cites W2114925922 @default.
- W2051270707 cites W2129508153 @default.
- W2051270707 cites W2132199758 @default.
- W2051270707 cites W2137415977 @default.
- W2051270707 cites W2139615023 @default.
- W2051270707 cites W2166361332 @default.
- W2051270707 cites W2167014117 @default.
- W2051270707 cites W2167960364 @default.
- W2051270707 cites W2172094535 @default.
- W2051270707 cites W2191114446 @default.
- W2051270707 cites W2231219683 @default.
- W2051270707 cites W2329530086 @default.
- W2051270707 cites W2329628078 @default.
- W2051270707 cites W2340939741 @default.
- W2051270707 cites W2395719099 @default.
- W2051270707 cites W2408238623 @default.
- W2051270707 cites W2416635055 @default.
- W2051270707 cites W4211094368 @default.
- W2051270707 cites W4385084698 @default.
- W2051270707 cites W63263670 @default.
- W2051270707 cites W95733417 @default.
- W2051270707 doi "https://doi.org/10.1152/ajprenal.00394.2003" @default.
- W2051270707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15126249" @default.
- W2051270707 hasPublicationYear "2004" @default.
- W2051270707 type Work @default.
- W2051270707 sameAs 2051270707 @default.
- W2051270707 citedByCount "32" @default.
- W2051270707 countsByYear W20512707072012 @default.
- W2051270707 countsByYear W20512707072013 @default.
- W2051270707 countsByYear W20512707072014 @default.
- W2051270707 countsByYear W20512707072015 @default.
- W2051270707 countsByYear W20512707072016 @default.
- W2051270707 countsByYear W20512707072018 @default.
- W2051270707 countsByYear W20512707072020 @default.
- W2051270707 crossrefType "journal-article" @default.
- W2051270707 hasAuthorship W2051270707A5016230294 @default.
- W2051270707 hasAuthorship W2051270707A5021269788 @default.
- W2051270707 hasConcept C105702510 @default.
- W2051270707 hasConcept C12554922 @default.
- W2051270707 hasConcept C126322002 @default.
- W2051270707 hasConcept C146957229 @default.
- W2051270707 hasConcept C170493617 @default.
- W2051270707 hasConcept C178790620 @default.
- W2051270707 hasConcept C181199279 @default.
- W2051270707 hasConcept C185592680 @default.
- W2051270707 hasConcept C2775838275 @default.
- W2051270707 hasConcept C2777622882 @default.
- W2051270707 hasConcept C28406088 @default.
- W2051270707 hasConcept C4001165 @default.
- W2051270707 hasConcept C50254741 @default.
- W2051270707 hasConcept C519581460 @default.
- W2051270707 hasConcept C55493867 @default.
- W2051270707 hasConcept C71924100 @default.
- W2051270707 hasConcept C86803240 @default.
- W2051270707 hasConceptScore W2051270707C105702510 @default.
- W2051270707 hasConceptScore W2051270707C12554922 @default.
- W2051270707 hasConceptScore W2051270707C126322002 @default.
- W2051270707 hasConceptScore W2051270707C146957229 @default.
- W2051270707 hasConceptScore W2051270707C170493617 @default.
- W2051270707 hasConceptScore W2051270707C178790620 @default.
- W2051270707 hasConceptScore W2051270707C181199279 @default.
- W2051270707 hasConceptScore W2051270707C185592680 @default.
- W2051270707 hasConceptScore W2051270707C2775838275 @default.
- W2051270707 hasConceptScore W2051270707C2777622882 @default.
- W2051270707 hasConceptScore W2051270707C28406088 @default.
- W2051270707 hasConceptScore W2051270707C4001165 @default.
- W2051270707 hasConceptScore W2051270707C50254741 @default.
- W2051270707 hasConceptScore W2051270707C519581460 @default.
- W2051270707 hasConceptScore W2051270707C55493867 @default.