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- W2051270944 abstract "Abstract Bovine adrenal 20α-hydroxysteroid oxido-reductase has been measured in the glands from animals of various ages. The substrates 20α-hydroxyprogesterone and 17α,20α-dihydroxyprogesterone were employed under conditions favoring oxidation. The highest activity was found in the newborn and older but prepuberal glands and very little in fetal or mature tissue. This activity was notable with 20α-hydroxyprogesterone whereas 17α,20α-dihydroxyprogesterone remained unoxidized. These findings with respect to age may partly explain the adrenarche wherein the production of C-19 steroids by the adrenal rises sharply around the time of sexual maturation. Some work indicates that 20-keto and not 20-hydroxy C-21 steroids are precursors to side chain cleavage. The higher level of 20-hydroxysteroid oxido-reductase activity in the prepuberal organs suggests that this enzyme diverts possible C-21 precursors from this cleavage reaction." @default.
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- W2051270944 date "1976-09-01" @default.
- W2051270944 modified "2023-09-27" @default.
- W2051270944 title "Bovine adrenal 20α-hydroxysteroid oxido-reductase and variations of activity with age" @default.
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- W2051270944 doi "https://doi.org/10.1016/0022-4731(76)90066-2" @default.
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