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- W2051275030 abstract "Discontinuation of an ACE-inhibitor because of cough occurs in 4-20% of people with hypertension, and often disappoints both physician and patient. To examine the blood pressure (BP) responses in people who exhibit ACE-inhibitor-associated cough, a registry of patients receiving a first-ever prescription for an ACE-inhibitor from 1985-92 was re-examined (see Clin Pharm Ther., 1996;:582). Surveillance for cough was prospective, systematic, and constant, and routinely included a trial of sinusitis therapy, followed by withdrawal and rechallenge before ultimate discontinuation of the ACE-inhibitor. Three groups were compared. Sixty-six (58±2 years old, 32% male, 94% black, initial BP: 176±3/99±2 mm Hg) ultimately discontinued the ACE-inhibitor because of cough. One hundred twenty-one (55±1 years old, 44% male, 75% black, initial BP: 169±2/98±1 mm Hg) discontinued the ACE-inhibitor for reasons other than cough. Three hundred five (54±1 years old, 44% male, 75% black, initial BP: 169±2/99±1 mm Hg) continued taking ACE-inhibitor therapy without adverse effects. Blood pressures were measured by the same clinician using standard techniques before and after 4±2 weeks of therapy with the usual starting dose of an ACE-inhibitor. Data are presented as mean±standard error. Those who coughed (“Coughers”) were compared to each of the other two groups using unpaired t-tests (for change in [Δ] BP, in mm Hg) and chi-square tests (for % achieving BP ≤ 140/90 mm Hg while taking the ACE-inhibitor). These data suggest that patients who cough with an ACE-inhibitor have a significantly greater blood pressure lowering with the ACE-inhibitor than those who do not cough, and are consistent with the view that bradykinin plays an important role in BP reduction with ACE-inhibitors. It remains to be established whether a similarly greater blood pressure lowering is seen in these patients (compared to those who do not cough) after an angiotensin II receptor blocker is prescribed. (See Table)" @default.
- W2051275030 created "2016-06-24" @default.
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- W2051275030 date "2002-04-01" @default.
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- W2051275030 title "Better blood pressure response in patients with ACE-inhibitor-associated cough" @default.
- W2051275030 doi "https://doi.org/10.1016/s0895-7061(02)02379-8" @default.
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