Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051275270> ?p ?o ?g. }
- W2051275270 endingPage "144" @default.
- W2051275270 startingPage "139" @default.
- W2051275270 abstract "It is well established that blocking the renin-angiotensin-aldosterone system (RAAS) is effective for the treatment of cardiovascular and renal complications in hypertension and diabetes mellitus. Although the induction of transforming growth factor beta1 (TGFbeta1) by components of the RAAS mediates the hypertrophic and fibrogenic changes in cardiovascular-renal complications, it is still controversial as to whether TGFbeta1 can be a target to prevent such complications. Here, we review recent findings on the role of TGFbeta1 in fluid homeostasis, focusing on the relationship with aldosterone.TGFbeta1 suppresses the adrenal production of aldosterone and renal tubular sodium reabsorption. We have generated mice with TGFbeta1 mRNA expression graded in five steps, from 10 to 300% of normal, and found that blood pressure and plasma volume are negatively regulated by TGFbeta1. Notably, the 10% hypomorph exhibits primary aldosteronism and sodium and water retention due to markedly impaired urinary excretion of water and electrolytes.These results identify TGFbeta signalling as an important counterregulatory system against aldosterone. Understanding the molecular mechanisms for the suppressive effects of TGFbeta1 on adrenocortical and renal function may further our understanding of primary aldosteronism, as well as assist in the development of novel therapeutic strategies for hypertension." @default.
- W2051275270 created "2016-06-24" @default.
- W2051275270 creator A5028775406 @default.
- W2051275270 creator A5030153875 @default.
- W2051275270 creator A5070335657 @default.
- W2051275270 creator A5081032642 @default.
- W2051275270 creator A5091435401 @default.
- W2051275270 date "2015-03-01" @default.
- W2051275270 modified "2023-10-02" @default.
- W2051275270 title "Transforming growth factor beta1 and aldosterone" @default.
- W2051275270 cites W1521640407 @default.
- W2051275270 cites W1940169239 @default.
- W2051275270 cites W1964217202 @default.
- W2051275270 cites W1965301500 @default.
- W2051275270 cites W1966080912 @default.
- W2051275270 cites W1971097876 @default.
- W2051275270 cites W1973112262 @default.
- W2051275270 cites W1973314853 @default.
- W2051275270 cites W1977873240 @default.
- W2051275270 cites W1984261567 @default.
- W2051275270 cites W1984483700 @default.
- W2051275270 cites W1987111346 @default.
- W2051275270 cites W1990307219 @default.
- W2051275270 cites W1990505305 @default.
- W2051275270 cites W1993396385 @default.
- W2051275270 cites W2000835501 @default.
- W2051275270 cites W2001124294 @default.
- W2051275270 cites W2005613978 @default.
- W2051275270 cites W2009442221 @default.
- W2051275270 cites W2010463731 @default.
- W2051275270 cites W2012096008 @default.
- W2051275270 cites W2014402389 @default.
- W2051275270 cites W2018598444 @default.
- W2051275270 cites W2020876708 @default.
- W2051275270 cites W2027270595 @default.
- W2051275270 cites W2029338338 @default.
- W2051275270 cites W2029933663 @default.
- W2051275270 cites W2030489236 @default.
- W2051275270 cites W2031762700 @default.
- W2051275270 cites W2033092347 @default.
- W2051275270 cites W2047944490 @default.
- W2051275270 cites W2051493175 @default.
- W2051275270 cites W2051921347 @default.
- W2051275270 cites W2056317902 @default.
- W2051275270 cites W2067401889 @default.
- W2051275270 cites W2082685929 @default.
- W2051275270 cites W2085832732 @default.
- W2051275270 cites W2087841314 @default.
- W2051275270 cites W2088234719 @default.
- W2051275270 cites W2090067193 @default.
- W2051275270 cites W2091597635 @default.
- W2051275270 cites W2091780020 @default.
- W2051275270 cites W2093971117 @default.
- W2051275270 cites W2111074462 @default.
- W2051275270 cites W2112497605 @default.
- W2051275270 cites W2113762991 @default.
- W2051275270 cites W2120245762 @default.
- W2051275270 cites W2122269095 @default.
- W2051275270 cites W2124701657 @default.
- W2051275270 cites W2139305453 @default.
- W2051275270 cites W2142305067 @default.
- W2051275270 cites W2152105966 @default.
- W2051275270 cites W2168855509 @default.
- W2051275270 cites W2171345475 @default.
- W2051275270 cites W2171880041 @default.
- W2051275270 cites W2172011106 @default.
- W2051275270 cites W2185381295 @default.
- W2051275270 cites W2208951677 @default.
- W2051275270 cites W2394914616 @default.
- W2051275270 cites W2400182527 @default.
- W2051275270 cites W2402359769 @default.
- W2051275270 cites W4249341602 @default.
- W2051275270 doi "https://doi.org/10.1097/mnh.0000000000000100" @default.
- W2051275270 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4838512" @default.
- W2051275270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25587902" @default.
- W2051275270 hasPublicationYear "2015" @default.
- W2051275270 type Work @default.
- W2051275270 sameAs 2051275270 @default.
- W2051275270 citedByCount "12" @default.
- W2051275270 countsByYear W20512752702016 @default.
- W2051275270 countsByYear W20512752702017 @default.
- W2051275270 countsByYear W20512752702019 @default.
- W2051275270 countsByYear W20512752702021 @default.
- W2051275270 countsByYear W20512752702022 @default.
- W2051275270 countsByYear W20512752702023 @default.
- W2051275270 crossrefType "journal-article" @default.
- W2051275270 hasAuthorship W2051275270A5028775406 @default.
- W2051275270 hasAuthorship W2051275270A5030153875 @default.
- W2051275270 hasAuthorship W2051275270A5070335657 @default.
- W2051275270 hasAuthorship W2051275270A5081032642 @default.
- W2051275270 hasAuthorship W2051275270A5091435401 @default.
- W2051275270 hasBestOaLocation W20512752702 @default.
- W2051275270 hasConcept C118131993 @default.
- W2051275270 hasConcept C126322002 @default.
- W2051275270 hasConcept C134018914 @default.
- W2051275270 hasConcept C198710026 @default.
- W2051275270 hasConcept C2778525890 @default.
- W2051275270 hasConcept C2780091579 @default.