Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051275859> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2051275859 endingPage "2715" @default.
- W2051275859 startingPage "2708" @default.
- W2051275859 abstract "Abstract: Distribution of iron in the brain varies with region, cell type, and age. Furthermore, some neurological diseases are accompanied by an abnormal accumulation of iron in specific areas of the CNS. These findings implicate a mobile intracerebral iron pool; however, transport of iron across the blood-brain barrier and its regulation are largely unknown. In an extensive series of experiments in primary cultures of porcine blood-brain barrier endothelial cells, we separately quantified surface-bound and total cellular transferrin receptor pools. Although 90% of all transferrin receptors were located inside the cell, only 10% of these intracellular receptors actively took part in the endocytic cycle. This large “inactive” intracellular transferrin receptor pool could either function as a storage site for spare receptors or be activated by the cell to increase its capacity for iron transport. Data were corrected for nonspecific binding by a separate biochemical assessment using a 100-fold excess of unlabeled ligand. Data were also analyzed in a nonlinear curve-fit program. This resulted in a less elaborate and less biased estimate of nonspecific binding." @default.
- W2051275859 created "2016-06-24" @default.
- W2051275859 creator A5004557187 @default.
- W2051275859 creator A5007552170 @default.
- W2051275859 creator A5033897264 @default.
- W2051275859 creator A5061626799 @default.
- W2051275859 creator A5067599085 @default.
- W2051275859 date "2002-11-23" @default.
- W2051275859 modified "2023-10-03" @default.
- W2051275859 title "Quantification of Different Transferrin Receptor Pools in Primary Cultures of Porcine Blood-Brain Barrier Endothelial Cells" @default.
- W2051275859 doi "https://doi.org/10.1046/j.1471-4159.1995.64062708.x" @default.
- W2051275859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7760051" @default.
- W2051275859 hasPublicationYear "2002" @default.
- W2051275859 type Work @default.
- W2051275859 sameAs 2051275859 @default.
- W2051275859 citedByCount "23" @default.
- W2051275859 countsByYear W20512758592015 @default.
- W2051275859 countsByYear W20512758592016 @default.
- W2051275859 countsByYear W20512758592017 @default.
- W2051275859 countsByYear W20512758592018 @default.
- W2051275859 countsByYear W20512758592019 @default.
- W2051275859 countsByYear W20512758592020 @default.
- W2051275859 countsByYear W20512758592021 @default.
- W2051275859 countsByYear W20512758592022 @default.
- W2051275859 countsByYear W20512758592023 @default.
- W2051275859 crossrefType "journal-article" @default.
- W2051275859 hasAuthorship W2051275859A5004557187 @default.
- W2051275859 hasAuthorship W2051275859A5007552170 @default.
- W2051275859 hasAuthorship W2051275859A5033897264 @default.
- W2051275859 hasAuthorship W2051275859A5061626799 @default.
- W2051275859 hasAuthorship W2051275859A5067599085 @default.
- W2051275859 hasConcept C134018914 @default.
- W2051275859 hasConcept C1491633281 @default.
- W2051275859 hasConcept C170493617 @default.
- W2051275859 hasConcept C185592680 @default.
- W2051275859 hasConcept C22814914 @default.
- W2051275859 hasConcept C2778402981 @default.
- W2051275859 hasConcept C28005876 @default.
- W2051275859 hasConcept C32264632 @default.
- W2051275859 hasConcept C529278444 @default.
- W2051275859 hasConcept C55493867 @default.
- W2051275859 hasConcept C79747257 @default.
- W2051275859 hasConcept C79879829 @default.
- W2051275859 hasConcept C86803240 @default.
- W2051275859 hasConcept C95444343 @default.
- W2051275859 hasConceptScore W2051275859C134018914 @default.
- W2051275859 hasConceptScore W2051275859C1491633281 @default.
- W2051275859 hasConceptScore W2051275859C170493617 @default.
- W2051275859 hasConceptScore W2051275859C185592680 @default.
- W2051275859 hasConceptScore W2051275859C22814914 @default.
- W2051275859 hasConceptScore W2051275859C2778402981 @default.
- W2051275859 hasConceptScore W2051275859C28005876 @default.
- W2051275859 hasConceptScore W2051275859C32264632 @default.
- W2051275859 hasConceptScore W2051275859C529278444 @default.
- W2051275859 hasConceptScore W2051275859C55493867 @default.
- W2051275859 hasConceptScore W2051275859C79747257 @default.
- W2051275859 hasConceptScore W2051275859C79879829 @default.
- W2051275859 hasConceptScore W2051275859C86803240 @default.
- W2051275859 hasConceptScore W2051275859C95444343 @default.
- W2051275859 hasIssue "6" @default.
- W2051275859 hasLocation W20512758591 @default.
- W2051275859 hasLocation W20512758592 @default.
- W2051275859 hasOpenAccess W2051275859 @default.
- W2051275859 hasPrimaryLocation W20512758591 @default.
- W2051275859 hasRelatedWork W1541110228 @default.
- W2051275859 hasRelatedWork W1970974720 @default.
- W2051275859 hasRelatedWork W1998113473 @default.
- W2051275859 hasRelatedWork W2025059697 @default.
- W2051275859 hasRelatedWork W2027978484 @default.
- W2051275859 hasRelatedWork W2051275859 @default.
- W2051275859 hasRelatedWork W2066912376 @default.
- W2051275859 hasRelatedWork W2165456024 @default.
- W2051275859 hasRelatedWork W2264730682 @default.
- W2051275859 hasRelatedWork W4289539008 @default.
- W2051275859 hasVolume "64" @default.
- W2051275859 isParatext "false" @default.
- W2051275859 isRetracted "false" @default.
- W2051275859 magId "2051275859" @default.
- W2051275859 workType "article" @default.