FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051275990> ?p ?o ?g. }

• W2051275990 endingPage "656" @default.
• W2051275990 startingPage "656" @default.
• W2051275990 abstract "Weekly low-dose methotrexate (MTX) remains the mainstay of second-line therapy for rheumatoid arthritis (RA). We have previously reported that adenosine, acting at specific receptors on inflammatory cells, mediates the antiinflammatory effects of MTX in both in vitro and in vivo models of acute inflammation, but the mechanism by which MTX suppresses the chronic inflammation of arthritis remains controversial. The present study was undertaken to further investigate the means by which adenosine mediates the antiinflammatory effects of MTX.The effects of 2 nonselective adenosine receptor antagonists, theophylline and caffeine, were examined, using the rat adjuvant arthritis model of RA. These agents were given alone and in conjunction with MTX, and arthritis severity was assessed clinically, radiologically, and histologically. Since rodent adenosine A3 receptors are not blocked by theophylline, selective A1, A2A, and A2B receptor antagonists were tested as well.Control animals developed severe arthritis, which was markedly attenuated by weekly treatment with MTX (0.75 mg/kg/week). Neither theophylline alone nor caffeine alone (each at 10 mg/kg/day) significantly affected the severity of the arthritis, but both agents markedly reversed the effect of MTX as measured by a severity index, hindpaw swelling, and hindpaw ankylosis. Radiographic and histologic analyses confirmed these observations. Neither A1, A2A, nor A2B receptor antagonists affected the capacity of MTX to ameliorate inflammation in adjuvant arthritis.These results provide strong evidence that adenosine mediates the antiinflammatory effects of MTX in this model of RA. Moreover, the findings suggest that abstinence from caffeine, a ubiquitous food additive and medication, may enhance the therapeutic effects of MTX in RA." @default.
• W2051275990 created "2016-06-24" @default.
• W2051275990 creator A5001634762 @default.
• W2051275990 creator A5012402636 @default.
• W2051275990 creator A5025635511 @default.
• W2051275990 creator A5059516590 @default.
• W2051275990 creator A5064326185 @default.
• W2051275990 creator A5084472125 @default.
• W2051275990 date "2000-03-01" @default.
• W2051275990 modified "2023-10-14" @default.
• W2051275990 title "Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: Evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis" @default.
• W2051275990 cites W1505264265 @default.
• W2051275990 cites W1546909356 @default.
• W2051275990 cites W1570911552 @default.
• W2051275990 cites W1575186397 @default.
• W2051275990 cites W1620733855 @default.
• W2051275990 cites W181639090 @default.
• W2051275990 cites W193344852 @default.
• W2051275990 cites W1944355206 @default.
• W2051275990 cites W1971945576 @default.
• W2051275990 cites W1985406467 @default.
• W2051275990 cites W1990318519 @default.
• W2051275990 cites W1994030928 @default.
• W2051275990 cites W1995266165 @default.
• W2051275990 cites W2000117305 @default.
• W2051275990 cites W2000795392 @default.
• W2051275990 cites W2001110103 @default.
• W2051275990 cites W2003176540 @default.
• W2051275990 cites W2006505301 @default.
• W2051275990 cites W2007462827 @default.
• W2051275990 cites W2008993518 @default.
• W2051275990 cites W2023313582 @default.
• W2051275990 cites W2029736718 @default.
• W2051275990 cites W2047861739 @default.
• W2051275990 cites W2050420928 @default.
• W2051275990 cites W2054480154 @default.
• W2051275990 cites W2058471639 @default.
• W2051275990 cites W2063273053 @default.
• W2051275990 cites W2064891609 @default.
• W2051275990 cites W2066494830 @default.
• W2051275990 cites W2070265254 @default.
• W2051275990 cites W2088746083 @default.
• W2051275990 cites W2089182381 @default.
• W2051275990 cites W2090435917 @default.
• W2051275990 cites W2092816835 @default.
• W2051275990 cites W2094803435 @default.
• W2051275990 cites W2101087002 @default.
• W2051275990 cites W2101535048 @default.
• W2051275990 cites W2115173245 @default.
• W2051275990 cites W2126808563 @default.
• W2051275990 cites W2143919278 @default.
• W2051275990 cites W2152836517 @default.
• W2051275990 cites W2153062771 @default.
• W2051275990 cites W2157940881 @default.
• W2051275990 cites W2176820060 @default.
• W2051275990 cites W2202736130 @default.
• W2051275990 cites W2231300178 @default.
• W2051275990 cites W2281759796 @default.
• W2051275990 cites W2329605444 @default.
• W2051275990 cites W2417583419 @default.
• W2051275990 cites W29771769 @default.
• W2051275990 cites W983682067 @default.
• W2051275990 doi "https://doi.org/10.1002/1529-0131(200003)43:3<656::aid-anr23>3.0.co;2-h" @default.
• W2051275990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10728760" @default.
• W2051275990 hasPublicationYear "2000" @default.
• W2051275990 type Work @default.
• W2051275990 sameAs 2051275990 @default.
• W2051275990 citedByCount "172" @default.
• W2051275990 countsByYear W20512759902012 @default.
• W2051275990 countsByYear W20512759902013 @default.
• W2051275990 countsByYear W20512759902014 @default.
• W2051275990 countsByYear W20512759902015 @default.
• W2051275990 countsByYear W20512759902016 @default.
• W2051275990 countsByYear W20512759902017 @default.
• W2051275990 countsByYear W20512759902018 @default.
• W2051275990 countsByYear W20512759902019 @default.
• W2051275990 countsByYear W20512759902020 @default.
• W2051275990 countsByYear W20512759902021 @default.
• W2051275990 countsByYear W20512759902022 @default.
• W2051275990 countsByYear W20512759902023 @default.
• W2051275990 crossrefType "journal-article" @default.
• W2051275990 hasAuthorship W2051275990A5001634762 @default.
• W2051275990 hasAuthorship W2051275990A5012402636 @default.
• W2051275990 hasAuthorship W2051275990A5025635511 @default.
• W2051275990 hasAuthorship W2051275990A5059516590 @default.
• W2051275990 hasAuthorship W2051275990A5064326185 @default.
• W2051275990 hasAuthorship W2051275990A5084472125 @default.
• W2051275990 hasConcept C126322002 @default.
• W2051275990 hasConcept C170493617 @default.
• W2051275990 hasConcept C2776914184 @default.
• W2051275990 hasConcept C2776991684 @default.
• W2051275990 hasConcept C2777077863 @default.
• W2051275990 hasConcept C2777575956 @default.
• W2051275990 hasConcept C2778095195 @default.
• W2051275990 hasConcept C2778491162 @default.
• W2051275990 hasConcept C2778500429 @default.
• W2051275990 hasConcept C2778938600 @default.
• W2051275990 hasConcept C2781059491 @default.

• next