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- W2051276018 abstract "The permeation of CGS 16617 (3-[ (5-amino-1-carboxy-1S-pentyl)amino]-2,3,4,5-tetrahydro-2-oxo-3S-1H-1 benzazepine-1-acetic acid), a novel angiotensin converting enzyme (ACE) inhibitor, through isolated buccal and colonic mucosa in vitro is described. In buccal mucosa, the flux was greatest in the dog, followed by the rabbit and pig, with similar time lags in all species. In the rabbit, the steady-state flux was linearly related to the donor concentration which is indicative of diffusion as the absorptive mechanism. Electrophysiological parameters were monitored to assess tissue viability and, based on these parameters buccal mucosa may be classified as a moderately “tight” epithelium. The steady-state flux of CGS 16617 was 20- to 60-fold greater across colon compared to buccal mucosa. The steady-state flux of CGS 16617 across isolated colonic mucosa was similar in the rat, rabbit and mini-pig, and about 2- to 3-fold higher in the dog. In the rabbit and mini-pig, the flux was linearly related to donor concentration. In both the rabbit and the rat, the flux was inversely correlated with the electrical resistance of the tissue. Based on electrophysiological parameters, the colon is a moderately “leaky” epithelium." @default.
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- W2051276018 date "1992-03-01" @default.
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- W2051276018 title "Buccal and colonic absorption of CGS 16617, a novel ACE inhibitor" @default.
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- W2051276018 doi "https://doi.org/10.1016/0168-3659(92)90066-z" @default.
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