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- W2051277448 abstract "Aortic mural angiogenesis is a key pathologic feature of AAA disease. We previously reported that VEGF-receptor 2 expression correlated with experimental AAA progression. This study evaluated the influence of anti-VEGF-A monoclonal antibody (mAb) therapy on AAA formation and progression in the porcine pancreatic elastase (PPE) infusion model in C57Bl/6J mice. PPE-infused mice were given anti-VEGF-A neutralizing mAb or control mAb. Aortic aneurysm progression was evaluated via serial transabdominal in vivo ultrasonography and histology at sacrifice. In control mAb-treated mice, persistent and significant aortic enlargement was noted beginning the third day following PPE infusion. Anti-VEGF-A mAb treatment initiated 3 days prior to PPE infusion significantly attenuated PPE-induced aortic expansion. Histologically, the VEGA-A neutralization resulted in preserved medial smooth muscles and elastin, and reduced mural leukocyte infiltration and angiogenesis. Although anti-VEGF-A mAb treatment initiated 5 days following PPE infusion reduced mural inflammation, aortic diameters continued to enlarge. Anti-VEGF-A mAb prevents the initiation and subsequent progression of experimental AAAs. The mAb treatment has limited effects on existing aneurysms." @default.
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- W2051277448 date "2013-05-01" @default.
- W2051277448 modified "2023-09-27" @default.
- W2051277448 title "VEGF-A Neutralization Suppresses Experimental Abdominal Aortic Aneurysm (AAA) Formation" @default.
- W2051277448 doi "https://doi.org/10.1016/j.jvs.2013.02.200" @default.
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