FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051278243> ?p ?o ?g. }

• W2051278243 endingPage "6967" @default.
• W2051278243 startingPage "6961" @default.
• W2051278243 abstract "MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate target gene expression at the posttranscriptional level. Although recent studies have indicated that miR-146a is involved in the tumorigenesis of various types of malignancies, few studies have investigated its role in colorectal cancer. In the current study, we examined the expression of miR-146a in colorectal cancer tissue and adjacent normal controls using publicly available expression profiling data. We then conducted a population-based case-control study which included 554 colorectal cancer cases and 566 matched healthy controls to assess the association of a genetic variant (rs2910164) in miR-146a with colorectal cancer susceptibility. We observed decreased expression of miR-146a in rectal cancer tissue compared with adjacent normal controls (P < 0.001). Association between miR-146a rs2910164 polymorphism and risk of colorectal cancer was detected with effect modification by alcohol drinking status (P for interaction = 0.010). Among non-alcohol drinkers, individuals with CC/CG genotype had an increased risk of developing colorectal cancer compared with those carrying GG genotype (odds ratio (OR) = 1.63, 95 % confidence interval (CI): 1.07 ∼ 2.47). Our findings indicate an association between miR-146a dysregulation and colorectal cancer, and suggest that miR-146a may play a role in colorectal carcinogenesis. Further large population-based prospective studies as well as mechanistic investigations are warranted to validate our findings." @default.
• W2051278243 created "2016-06-24" @default.
• W2051278243 creator A5019345418 @default.
• W2051278243 creator A5021846370 @default.
• W2051278243 creator A5022303965 @default.
• W2051278243 creator A5044141896 @default.
• W2051278243 creator A5045309022 @default.
• W2051278243 creator A5049202649 @default.
• W2051278243 creator A5051914364 @default.
• W2051278243 creator A5070822333 @default.
• W2051278243 creator A5078988597 @default.
• W2051278243 creator A5083445181 @default.
• W2051278243 date "2014-04-17" @default.
• W2051278243 modified "2023-10-17" @default.
• W2051278243 title "Association of a genetic variant in microRNA-146a with risk of colorectal cancer: a population-based case-control study" @default.
• W2051278243 cites W1970752651 @default.
• W2051278243 cites W1972511235 @default.
• W2051278243 cites W1972987358 @default.
• W2051278243 cites W1992749719 @default.
• W2051278243 cites W1995735124 @default.
• W2051278243 cites W2000006839 @default.
• W2051278243 cites W2012380025 @default.
• W2051278243 cites W2012562363 @default.
• W2051278243 cites W2016024700 @default.
• W2051278243 cites W2023687830 @default.
• W2051278243 cites W2026595595 @default.
• W2051278243 cites W2027477052 @default.
• W2051278243 cites W2035033138 @default.
• W2051278243 cites W2035213975 @default.
• W2051278243 cites W2037387911 @default.
• W2051278243 cites W2045881743 @default.
• W2051278243 cites W2049963512 @default.
• W2051278243 cites W2062174772 @default.
• W2051278243 cites W2074571173 @default.
• W2051278243 cites W2075209536 @default.
• W2051278243 cites W2080832629 @default.
• W2051278243 cites W2081835397 @default.
• W2051278243 cites W2089401789 @default.
• W2051278243 cites W2098409220 @default.
• W2051278243 cites W2100651747 @default.
• W2051278243 cites W2106787323 @default.
• W2051278243 cites W2110041869 @default.
• W2051278243 cites W2121422066 @default.
• W2051278243 cites W2121659696 @default.
• W2051278243 cites W2126945850 @default.
• W2051278243 cites W2133124222 @default.
• W2051278243 cites W2139389450 @default.
• W2051278243 cites W2142801414 @default.
• W2051278243 cites W2150286564 @default.
• W2051278243 cites W2157155706 @default.
• W2051278243 cites W2157197396 @default.
• W2051278243 cites W2161163389 @default.
• W2051278243 cites W2162391007 @default.
• W2051278243 cites W2167619577 @default.
• W2051278243 doi "https://doi.org/10.1007/s13277-014-1916-y" @default.
• W2051278243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24740563" @default.
• W2051278243 hasPublicationYear "2014" @default.
• W2051278243 type Work @default.
• W2051278243 sameAs 2051278243 @default.
• W2051278243 citedByCount "21" @default.
• W2051278243 countsByYear W20512782432015 @default.
• W2051278243 countsByYear W20512782432016 @default.
• W2051278243 countsByYear W20512782432018 @default.
• W2051278243 countsByYear W20512782432019 @default.
• W2051278243 countsByYear W20512782432020 @default.
• W2051278243 countsByYear W20512782432021 @default.
• W2051278243 countsByYear W20512782432022 @default.
• W2051278243 countsByYear W20512782432023 @default.
• W2051278243 crossrefType "journal-article" @default.
• W2051278243 hasAuthorship W2051278243A5019345418 @default.
• W2051278243 hasAuthorship W2051278243A5021846370 @default.
• W2051278243 hasAuthorship W2051278243A5022303965 @default.
• W2051278243 hasAuthorship W2051278243A5044141896 @default.
• W2051278243 hasAuthorship W2051278243A5045309022 @default.
• W2051278243 hasAuthorship W2051278243A5049202649 @default.
• W2051278243 hasAuthorship W2051278243A5051914364 @default.
• W2051278243 hasAuthorship W2051278243A5070822333 @default.
• W2051278243 hasAuthorship W2051278243A5078988597 @default.
• W2051278243 hasAuthorship W2051278243A5083445181 @default.
• W2051278243 hasConcept C104317684 @default.
• W2051278243 hasConcept C121608353 @default.
• W2051278243 hasConcept C126322002 @default.
• W2051278243 hasConcept C135763542 @default.
• W2051278243 hasConcept C143998085 @default.
• W2051278243 hasConcept C145059251 @default.
• W2051278243 hasConcept C146304588 @default.
• W2051278243 hasConcept C156957248 @default.
• W2051278243 hasConcept C2908647359 @default.
• W2051278243 hasConcept C44249647 @default.
• W2051278243 hasConcept C526805850 @default.
• W2051278243 hasConcept C54355233 @default.
• W2051278243 hasConcept C555283112 @default.
• W2051278243 hasConcept C71924100 @default.
• W2051278243 hasConcept C86803240 @default.
• W2051278243 hasConcept C99454951 @default.
• W2051278243 hasConceptScore W2051278243C104317684 @default.
• W2051278243 hasConceptScore W2051278243C121608353 @default.
• W2051278243 hasConceptScore W2051278243C126322002 @default.

• next