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- W2051278645 abstract "Peroxisome proliferators (PP) are a large class of structurally dissimilar chemicals. These chemicals have diverse effects in rodents and humans, including regulation of lipid metabolism, growth promotion, and induction of hepatocarcinogenesis. Most, if not all, effects of PP are mediated by three members of the nuclear receptor superfamily called PP-activated receptors (PPAR). In this review, we discuss the evidence that PPARalpha, the predominant PPAR in the, liver is involved in the growth promoting and hepatocarcinogenic effects of PP." @default.
- W2051278645 created "2016-06-24" @default.
- W2051278645 creator A5006650991 @default.
- W2051278645 creator A5014837859 @default.
- W2051278645 creator A5073932699 @default.
- W2051278645 date "2000-03-01" @default.
- W2051278645 modified "2023-10-03" @default.
- W2051278645 title "Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators" @default.
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- W2051278645 doi "https://doi.org/10.1016/s0027-5107(99)00232-8" @default.
- W2051278645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10725468" @default.
- W2051278645 hasPublicationYear "2000" @default.
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