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- W2051279458 abstract "<h3>To the Editor:—</h3> The editorial Cyanoacrylate Tissue Adhesives (<b>201</b>:195, 1967) deserves comment. Experimental observations<sup>1,2</sup>have demonstrated a dichotomy among the alkyl-2-cyanoacrylates in regard to local toxicity. The methyl and ethyl esters are locally toxic, but the higher homologues, such as n-butyl, n-pentyl, n-hexyl, and n-decyl are not. We did not report<sup>1</sup>that as one proceeds up the homologous series, histotoxicity decreases, but rather showed that the methyl homologue was logically toxic whereas the hexyl and decyl homologues were not. The latter two materials evoked similar responses. In regard to rates of polymerization, these rates can be varied for any monomer. They are directly related to purity of the monomer, surface area exposed to catalysis, and effective catalyst concentration and are inversely related to the local concentration of acidic inhibitor substances. These factors, especially purity of the monomer, control polymerization time. Thus factors other than rate of polymerization" @default.
- W2051279458 created "2016-06-24" @default.
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- W2051279458 date "1967-09-25" @default.
- W2051279458 modified "2023-10-18" @default.
- W2051279458 title "Cyanoacrylate Tissue Adhesives" @default.
- W2051279458 cites W2405709475 @default.
- W2051279458 doi "https://doi.org/10.1001/jama.1967.03130130078029" @default.
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