FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051279466> ?p ?o ?g. }

• W2051279466 endingPage "477" @default.
• W2051279466 startingPage "472" @default.
• W2051279466 abstract "We have recently shown that ATP-sensitive potassium (K(ATP)) channels in the heart are localized in the caveolae of cardiac myocytes and regulated by caveolae-related signaling. However, little is known about the role of caveolins, signature proteins of caveolae, in cardiac K(ATP) channel function. The present study was designed to explore the potential functional interaction between caveolin-3 and K(ATP) channels. The cardiac K(ATP) channel subunits Kir6.2 and SUR2A were transiently transfected in HEK293T cells with or without co-transfection of caveolin-3 or caveolin-1. Our data demonstrated that the recombinant K(ATP) channel activity in HEK293T cells was inhibited by expression of caveolin-3, but not caveolin-1. The application of caveolin-3 scaffolding domain peptide, corresponding to amino acid residues 55-74 of caveolin-3, blocked the inhibitory effect of caveolin-3 on K(ATP) channels. However, the same peptide did not have any significant effect on K(ATP) channels in HEK293T cells without caveolin-3 expression. We further confirmed that K(ATP) channels co-immunoprecipitated with caveolin-3 but not caveolin-1. The association of K(ATP) channels with caveolin-3 was largely prevented by caveolin-3 scaffolding domain peptide. Our results indicate that caveolin-3 negatively regulates Kir6.2/SUR2A channel function." @default.
• W2051279466 created "2016-06-24" @default.
• W2051279466 creator A5002332074 @default.
• W2051279466 creator A5035718600 @default.
• W2051279466 creator A5061998550 @default.
• W2051279466 date "2009-07-01" @default.
• W2051279466 modified "2023-10-13" @default.
• W2051279466 title "Caveolin-3 negatively regulates recombinant cardiac KATP channels" @default.
• W2051279466 cites W1571734887 @default.
• W2051279466 cites W1965209959 @default.
• W2051279466 cites W1983976982 @default.
• W2051279466 cites W1993353490 @default.
• W2051279466 cites W1998493493 @default.
• W2051279466 cites W2004617058 @default.
• W2051279466 cites W2030727312 @default.
• W2051279466 cites W2031083012 @default.
• W2051279466 cites W2036497297 @default.
• W2051279466 cites W2056757839 @default.
• W2051279466 cites W2062372028 @default.
• W2051279466 cites W2064953660 @default.
• W2051279466 cites W2075796682 @default.
• W2051279466 cites W2092437783 @default.
• W2051279466 cites W2101235425 @default.
• W2051279466 cites W2106292095 @default.
• W2051279466 cites W2123261495 @default.
• W2051279466 cites W2136556999 @default.
• W2051279466 cites W2144899729 @default.
• W2051279466 cites W2148904112 @default.
• W2051279466 cites W2149390328 @default.
• W2051279466 cites W2150930622 @default.
• W2051279466 cites W2153144629 @default.
• W2051279466 cites W2166968378 @default.
• W2051279466 doi "https://doi.org/10.1016/j.bbrc.2009.05.100" @default.
• W2051279466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19481058" @default.
• W2051279466 hasPublicationYear "2009" @default.
• W2051279466 type Work @default.
• W2051279466 sameAs 2051279466 @default.
• W2051279466 citedByCount "17" @default.
• W2051279466 countsByYear W20512794662012 @default.
• W2051279466 countsByYear W20512794662013 @default.
• W2051279466 countsByYear W20512794662014 @default.
• W2051279466 countsByYear W20512794662015 @default.
• W2051279466 countsByYear W20512794662016 @default.
• W2051279466 countsByYear W20512794662017 @default.
• W2051279466 countsByYear W20512794662018 @default.
• W2051279466 countsByYear W20512794662020 @default.
• W2051279466 countsByYear W20512794662021 @default.
• W2051279466 countsByYear W20512794662022 @default.
• W2051279466 crossrefType "journal-article" @default.
• W2051279466 hasAuthorship W2051279466A5002332074 @default.
• W2051279466 hasAuthorship W2051279466A5035718600 @default.
• W2051279466 hasAuthorship W2051279466A5061998550 @default.
• W2051279466 hasConcept C104317684 @default.
• W2051279466 hasConcept C12554922 @default.
• W2051279466 hasConcept C170493617 @default.
• W2051279466 hasConcept C174510640 @default.
• W2051279466 hasConcept C185592680 @default.
• W2051279466 hasConcept C207200792 @default.
• W2051279466 hasConcept C2776410257 @default.
• W2051279466 hasConcept C2779403975 @default.
• W2051279466 hasConcept C2780870201 @default.
• W2051279466 hasConcept C49866891 @default.
• W2051279466 hasConcept C54009773 @default.
• W2051279466 hasConcept C55493867 @default.
• W2051279466 hasConcept C62478195 @default.
• W2051279466 hasConcept C71829478 @default.
• W2051279466 hasConcept C83743174 @default.
• W2051279466 hasConcept C86803240 @default.
• W2051279466 hasConcept C95444343 @default.
• W2051279466 hasConceptScore W2051279466C104317684 @default.
• W2051279466 hasConceptScore W2051279466C12554922 @default.
• W2051279466 hasConceptScore W2051279466C170493617 @default.
• W2051279466 hasConceptScore W2051279466C174510640 @default.
• W2051279466 hasConceptScore W2051279466C185592680 @default.
• W2051279466 hasConceptScore W2051279466C207200792 @default.
• W2051279466 hasConceptScore W2051279466C2776410257 @default.
• W2051279466 hasConceptScore W2051279466C2779403975 @default.
• W2051279466 hasConceptScore W2051279466C2780870201 @default.
• W2051279466 hasConceptScore W2051279466C49866891 @default.
• W2051279466 hasConceptScore W2051279466C54009773 @default.
• W2051279466 hasConceptScore W2051279466C55493867 @default.
• W2051279466 hasConceptScore W2051279466C62478195 @default.
• W2051279466 hasConceptScore W2051279466C71829478 @default.
• W2051279466 hasConceptScore W2051279466C83743174 @default.
• W2051279466 hasConceptScore W2051279466C86803240 @default.
• W2051279466 hasConceptScore W2051279466C95444343 @default.
• W2051279466 hasIssue "3" @default.
• W2051279466 hasLocation W20512794661 @default.
• W2051279466 hasLocation W20512794662 @default.
• W2051279466 hasOpenAccess W2051279466 @default.
• W2051279466 hasPrimaryLocation W20512794661 @default.
• W2051279466 hasRelatedWork W1976350481 @default.
• W2051279466 hasRelatedWork W2026100135 @default.
• W2051279466 hasRelatedWork W2072550205 @default.
• W2051279466 hasRelatedWork W2091701987 @default.
• W2051279466 hasRelatedWork W2139345025 @default.
• W2051279466 hasRelatedWork W2159413140 @default.
• W2051279466 hasRelatedWork W2165467938 @default.

• next