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• W2051279593 abstract "Sensitization is manifested as an increased response of neurones to a variety of inputs following intense or noxious stimuli. It is one of the simplest forms of learning and synaptic plasticity and it represents an important feature of nociception. In the spinal cord, repeated stimulation (at constant strength) of dorsal root afferents including nociceptive C fibres can elicit a progressive increase in the number of action potentials generated by motoneurones and interneurones. This phenomenon is termed action potential windup and is used as a cellular model of pain sensitization developing at the level of the central nervous system. Understanding the mechanisms responsible for windup generation might allow clarification of the cellular mechanisms of pain signalling and development of new strategies for pain treatment. Action potential windup is observed in a minority of cells only, indicating that certain cell-specific mechanisms are responsible for its generation. The most reliable index to predict windup generation is the rate at which the membrane potential is depolarized during repetitive stimulation. This phenomenon has been proposed to be due to gradual recruitment of NMDA receptor activity, to summation of slow excitatory potentials mediated by substance P (and related peptides) or to facilitation of slow calcium channels by metabotropic glutamate receptors. Little is known about the role of synaptic inhibition in windup, although it should not be underestimated. Each theory per se is unable to account for all the experimental observations. Since NMDA receptors are involved in many forms of synaptic plasticity, additional mechanisms such as summation of slow peptidergic potentials, facilitation of slow Ca2+ currents and disinhibition are proposed as necessary to impart specificity to pain-induced sensitization. These additional mechanisms might be species specific and change during development or chronic pain states." @default.
• W2051279593 created "2016-06-24" @default.
• W2051279593 creator A5012502415 @default.
• W2051279593 creator A5042838362 @default.
• W2051279593 date "1998-01-01" @default.
• W2051279593 modified "2023-10-08" @default.
• W2051279593 title "SENSITIZATION OF PAIN PATHWAYS IN THE SPINAL CORD: CELLULAR MECHANISMS" @default.
• W2051279593 cites W103811464 @default.
• W2051279593 cites W1483867462 @default.
• W2051279593 cites W1577210222 @default.
• W2051279593 cites W1794801390 @default.
• W2051279593 cites W1797972710 @default.
• W2051279593 cites W1809981752 @default.
• W2051279593 cites W1860985526 @default.
• W2051279593 cites W187798037 @default.
• W2051279593 cites W1881168708 @default.
• W2051279593 cites W1945096581 @default.
• W2051279593 cites W1965204194 @default.
• W2051279593 cites W1965948569 @default.
• W2051279593 cites W1966200304 @default.
• W2051279593 cites W1966917856 @default.
• W2051279593 cites W1966918072 @default.
• W2051279593 cites W1967559024 @default.
• W2051279593 cites W1967598734 @default.
• W2051279593 cites W1971074933 @default.
• W2051279593 cites W1972522862 @default.
• W2051279593 cites W1976798000 @default.
• W2051279593 cites W1978664632 @default.
• W2051279593 cites W1979638175 @default.
• W2051279593 cites W1979729387 @default.
• W2051279593 cites W1980325410 @default.
• W2051279593 cites W1981468995 @default.
• W2051279593 cites W1982276226 @default.
• W2051279593 cites W1984095038 @default.
• W2051279593 cites W1984459952 @default.
• W2051279593 cites W1987781967 @default.
• W2051279593 cites W1988059170 @default.
• W2051279593 cites W1988963823 @default.
• W2051279593 cites W1989041973 @default.
• W2051279593 cites W1991550485 @default.
• W2051279593 cites W1994136876 @default.
• W2051279593 cites W1994518185 @default.
• W2051279593 cites W1996806279 @default.
• W2051279593 cites W1997568797 @default.
• W2051279593 cites W1997684997 @default.
• W2051279593 cites W1997714059 @default.
• W2051279593 cites W1998175383 @default.
• W2051279593 cites W1998347917 @default.
• W2051279593 cites W2000210882 @default.
• W2051279593 cites W2000837560 @default.
• W2051279593 cites W2001947839 @default.
• W2051279593 cites W2002901944 @default.
• W2051279593 cites W2003612759 @default.
• W2051279593 cites W2004624137 @default.
• W2051279593 cites W2007174401 @default.
• W2051279593 cites W2007297463 @default.
• W2051279593 cites W2009477456 @default.
• W2051279593 cites W2014663128 @default.
• W2051279593 cites W2014779151 @default.
• W2051279593 cites W2017392376 @default.
• W2051279593 cites W2019186139 @default.
• W2051279593 cites W2021110549 @default.
• W2051279593 cites W2023065608 @default.
• W2051279593 cites W2025282840 @default.
• W2051279593 cites W2032895441 @default.
• W2051279593 cites W2033368748 @default.
• W2051279593 cites W2035331415 @default.
• W2051279593 cites W2036219423 @default.
• W2051279593 cites W2039136299 @default.
• W2051279593 cites W2040751295 @default.
• W2051279593 cites W2041630699 @default.
• W2051279593 cites W2044126921 @default.
• W2051279593 cites W2045812316 @default.
• W2051279593 cites W2046420598 @default.
• W2051279593 cites W2046593983 @default.
• W2051279593 cites W2047295469 @default.
• W2051279593 cites W2047327104 @default.
• W2051279593 cites W2049828459 @default.
• W2051279593 cites W2051318074 @default.
• W2051279593 cites W2053643995 @default.
• W2051279593 cites W2054862674 @default.
• W2051279593 cites W2056636316 @default.
• W2051279593 cites W2058687743 @default.
• W2051279593 cites W2062625412 @default.
• W2051279593 cites W2067393403 @default.
• W2051279593 cites W2067995523 @default.
• W2051279593 cites W2068129263 @default.
• W2051279593 cites W2071715974 @default.
• W2051279593 cites W2072492488 @default.
• W2051279593 cites W2074375990 @default.
• W2051279593 cites W2075285126 @default.
• W2051279593 cites W2077348695 @default.
• W2051279593 cites W2080869223 @default.
• W2051279593 cites W2083524662 @default.
• W2051279593 cites W2084213330 @default.
• W2051279593 cites W2084461986 @default.
• W2051279593 cites W2087825631 @default.
• W2051279593 cites W2090389394 @default.

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