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- W2051280023 abstract "Comment This is a complex paper for a clinician, but it suggests that, at least in this animal model, high-intrinsic-efficacy opioids (indicating a maximal drug effect with less man complete receptor occupancy) have a lesser tendency to produce tolerance when administered by infusion man those of lesser efficacy. Thus, for longer-term administration by infusion, fentanyl may be a more appropriate opioid than morphine. There are no data to indicate whether this applies to different routes of infusion administration. Obviously, human studies would be needed to confirm or refute this suggestion. Given that under some circumstances long-term opioid infusions are an important part of clinical management, these observations are worthy of further consideration." @default.
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- W2051280023 date "1996-10-01" @default.
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- W2051280023 title "The Effect of Intrinsic Efficacy on Opioid Tolerance" @default.
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