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• W2051280251 endingPage "1102" @default.
• W2051280251 startingPage "1092" @default.
• W2051280251 abstract "This paper provides a brief overview of how we got involved in fMRI work and of our efforts to elucidate the mechanisms underlying BOLD signal changes. The phenomenon discussed here in particular is the post-stimulus undershoot (PSU), the interpretation of which has captivated many fMRI scientists and is still under debate to date. This controversy is caused both by the convoluted physiological origin of the BOLD effect, which allows many possible explanations, and the lack of comprehensive data in the early years. BOLD effects reflect changes in cerebral blood flow (CBF), volume (CBV), metabolic rate of oxygen (CMRO2), and hematocrit fraction (Hct). However, the size of such effects is modulated by vascular origin such as intravascular, extravascular, macro and microvascular, venular and capillary, the relative contributions of which depend not only on the spatial resolution of the measurements, but also on stimulus duration, on magnetic field strength and on whether spin echo (SE) or gradient echo (GRE) detection is used. The two most dominant explanations of the PSU have been delayed vascular compliance (first venular, later arteriolar, and recently capillary) and sustained increases in CMRO2, while post-activation reduction in CBF is a distant third. MRI has the capability to independently measure CBF and arteriolar, venous, and total CBV contributions in humans and animals, which has been of great assistance in improving the understanding of BOLD phenomena. Using currently available MRI and optical data, we conclude that the predominant PSU origin is a sustained increase in CMRO2. However, some contributions from delayed vascular compliance are likely, and small CBF undershoot contributions that are difficult to detect with current arterial spin labeling technology can also not be excluded. The relative contribution of these different processes, which are not mutually exclusive and can act together, is likely to vary with stimulus duration and type." @default.
• W2051280251 created "2016-06-24" @default.
• W2051280251 creator A5023293183 @default.
• W2051280251 creator A5033765540 @default.
• W2051280251 creator A5086526292 @default.
• W2051280251 date "2012-08-01" @default.
• W2051280251 modified "2023-10-18" @default.
• W2051280251 title "The BOLD post-stimulus undershoot, one of the most debated issues in fMRI" @default.
• W2051280251 cites W1537911849 @default.
• W2051280251 cites W1605713159 @default.
• W2051280251 cites W1965315090 @default.
• W2051280251 cites W1968746303 @default.
• W2051280251 cites W1970124993 @default.
• W2051280251 cites W1970382304 @default.
• W2051280251 cites W1974829879 @default.
• W2051280251 cites W1980086703 @default.
• W2051280251 cites W1982120171 @default.
• W2051280251 cites W1986129651 @default.
• W2051280251 cites W1990241978 @default.
• W2051280251 cites W1993226828 @default.
• W2051280251 cites W1994431325 @default.
• W2051280251 cites W1996964516 @default.
• W2051280251 cites W1999665362 @default.
• W2051280251 cites W2002051532 @default.
• W2051280251 cites W2002398814 @default.
• W2051280251 cites W2002660165 @default.
• W2051280251 cites W2006209961 @default.
• W2051280251 cites W2007192266 @default.
• W2051280251 cites W2007830779 @default.
• W2051280251 cites W2008432587 @default.
• W2051280251 cites W2008718302 @default.
• W2051280251 cites W2009283203 @default.
• W2051280251 cites W2010127368 @default.
• W2051280251 cites W2013713875 @default.
• W2051280251 cites W2018228708 @default.
• W2051280251 cites W2018593624 @default.
• W2051280251 cites W2018806285 @default.
• W2051280251 cites W2019540655 @default.
• W2051280251 cites W2022892278 @default.
• W2051280251 cites W2024762951 @default.
• W2051280251 cites W2028669436 @default.
• W2051280251 cites W2032800983 @default.
• W2051280251 cites W2033131840 @default.
• W2051280251 cites W2034462852 @default.
• W2051280251 cites W2035909316 @default.
• W2051280251 cites W2038040839 @default.
• W2051280251 cites W2039964935 @default.
• W2051280251 cites W2040032797 @default.
• W2051280251 cites W2042140315 @default.
• W2051280251 cites W2042422091 @default.
• W2051280251 cites W2042522004 @default.
• W2051280251 cites W2042698075 @default.
• W2051280251 cites W2042873520 @default.
• W2051280251 cites W2045026301 @default.
• W2051280251 cites W2047751376 @default.
• W2051280251 cites W2052880826 @default.
• W2051280251 cites W2053276939 @default.
• W2051280251 cites W2054130199 @default.
• W2051280251 cites W2057376755 @default.
• W2051280251 cites W2058187666 @default.
• W2051280251 cites W2058352845 @default.
• W2051280251 cites W2060318115 @default.
• W2051280251 cites W2060319077 @default.
• W2051280251 cites W2064533924 @default.
• W2051280251 cites W2065218488 @default.
• W2051280251 cites W2066349780 @default.
• W2051280251 cites W2067459714 @default.
• W2051280251 cites W2069734928 @default.
• W2051280251 cites W2070396441 @default.
• W2051280251 cites W2074070767 @default.
• W2051280251 cites W2074283724 @default.
• W2051280251 cites W2075513166 @default.
• W2051280251 cites W2076106148 @default.
• W2051280251 cites W2077790688 @default.
• W2051280251 cites W2078619025 @default.
• W2051280251 cites W2079716456 @default.
• W2051280251 cites W2083136232 @default.
• W2051280251 cites W2085235340 @default.
• W2051280251 cites W2085655437 @default.
• W2051280251 cites W2087028925 @default.
• W2051280251 cites W2088774650 @default.
• W2051280251 cites W2098617171 @default.
• W2051280251 cites W2108049514 @default.
• W2051280251 cites W2114104729 @default.
• W2051280251 cites W2116671408 @default.
• W2051280251 cites W2123526233 @default.
• W2051280251 cites W2123586737 @default.
• W2051280251 cites W2132471437 @default.
• W2051280251 cites W2132513225 @default.
• W2051280251 cites W2137547086 @default.
• W2051280251 cites W2137950689 @default.
• W2051280251 cites W2147412935 @default.
• W2051280251 cites W2148992333 @default.
• W2051280251 cites W2149153247 @default.
• W2051280251 cites W2149953389 @default.
• W2051280251 cites W2160349805 @default.
• W2051280251 cites W2160843257 @default.
• W2051280251 cites W2163234334 @default.

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