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- W2051280844 abstract "1. Oestradiol administration in castrated rats resulted in an increased activity of the cholesterolα-hydroxylase and a decreased activity of the drug oxidase enzyme systems. 2. Aqueous solutions of oestradiol (up to 25·10−6M) incubated in vitro with microsomes, binds into the microsomal membrane framework reducing the activity of both enzyme systems. 3. The specific activity of cholesterol 7α-hydroxylase. drops after 3 hr preincubation with oestradiol to at least 70% of its original value. 4. Actinomycin D and cycloheximide administration reduced the oestradiol-induced and control cholesterol 7α-hydroxylase activity to the same level, 6 hr after the injections." @default.
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- W2051280844 date "1982-01-01" @default.
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- W2051280844 title "Evoked effects of oestradiol on hepatic cholesterol 7α-hydroxylase and drug oxidase in castrated rats" @default.
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- W2051280844 doi "https://doi.org/10.1016/0020-711x(82)90102-1" @default.
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