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• W2051283001 abstract "Transforming growth factor-beta (TGF-beta) superfamily regulates matrix metalloproteinases (MMP), which intrinsically regulate various cell behaviors leading to metastasis. We investigated the effect of TGF-beta(2) on MMP-2 regulation in human bladder carcinoma cell line 5637. Zymography, ELISA, and real-time polymerase chain reaction revealed that TGF-beta(2) stimulated MMP-2 production, but the transcription of its gene remained unchanged. Wortmannin could not inhibit MMP-2 secretion and activity and conversely the amount of the protein and its enzymatic activity were increased. These data suggest that TGF-beta(2) increased MMP-2 at the posttranscriptional level and this upregulation was independent of phosphatidylinositol 3-kinase signaling pathway." @default.
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• W2051283001 date "2009-01-01" @default.
• W2051283001 modified "2023-09-30" @default.
• W2051283001 title "The Effect of TGF-β₂on MMP-2 Production and Activity in Highly Metastatic Human Bladder Carcinoma Cell Line 5637" @default.
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• W2051283001 doi "https://doi.org/10.1080/07357900802620810" @default.
• W2051283001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19219652" @default.
• W2051283001 hasPublicationYear "2009" @default.
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