FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051283118> ?p ?o ?g. }

• W2051283118 endingPage "7558" @default.
• W2051283118 startingPage "7553" @default.
• W2051283118 abstract "Phosphorylation is ubiquitous in control of protein activity, yet its effects on protein structure are poorly understood. Here we investigate the effect of serine phosphorylation in the interior of an alpha-helix when a salt bridge is present between the phosphate group and a positively charged side chain (in this case lysine) at i,i + 4 spacing. The stabilization of the helix is considerable and can overcome the intrinsically low preference of phosphoserine for the interior of the helix. The effect is pH dependent, as both the lysine and phosphate groups are titratable, and so calculations are given for several charge combinations. These results, with our previous work, highlight the different, context-dependent effects of phosphorylation in the alpha-helix. The interaction between the phosphate(2)(-) group and the lysine side chain is the strongest yet recorded in helix-coil studies. The results are of interest both in de novo design of peptides and in understanding the structural modes of control by phosphorylation." @default.
• W2051283118 created "2016-06-24" @default.
• W2051283118 creator A5000626384 @default.
• W2051283118 creator A5062461468 @default.
• W2051283118 date "2005-04-19" @default.
• W2051283118 modified "2023-10-05" @default.
• W2051283118 title "A Phosphoserine−Lysine Salt Bridge within an α-Helical Peptide, the Strongest α-Helix Side-Chain Interaction Measured to Date" @default.
• W2051283118 cites W1501199419 @default.
• W2051283118 cites W1548175159 @default.
• W2051283118 cites W1980807872 @default.
• W2051283118 cites W1987878435 @default.
• W2051283118 cites W2039321158 @default.
• W2051283118 cites W2043793450 @default.
• W2051283118 cites W2057657722 @default.
• W2051283118 cites W2085252844 @default.
• W2051283118 cites W2088756145 @default.
• W2051283118 cites W2154182570 @default.
• W2051283118 cites W2409039558 @default.
• W2051283118 cites W2423812888 @default.
• W2051283118 cites W4241259246 @default.
• W2051283118 doi "https://doi.org/10.1021/bi050297j" @default.
• W2051283118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1560106" @default.
• W2051283118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15895998" @default.
• W2051283118 hasPublicationYear "2005" @default.
• W2051283118 type Work @default.
• W2051283118 sameAs 2051283118 @default.
• W2051283118 citedByCount "61" @default.
• W2051283118 countsByYear W20512831182012 @default.
• W2051283118 countsByYear W20512831182013 @default.
• W2051283118 countsByYear W20512831182014 @default.
• W2051283118 countsByYear W20512831182015 @default.
• W2051283118 countsByYear W20512831182017 @default.
• W2051283118 countsByYear W20512831182018 @default.
• W2051283118 countsByYear W20512831182019 @default.
• W2051283118 countsByYear W20512831182020 @default.
• W2051283118 countsByYear W20512831182021 @default.
• W2051283118 countsByYear W20512831182022 @default.
• W2051283118 countsByYear W20512831182023 @default.
• W2051283118 crossrefType "journal-article" @default.
• W2051283118 hasAuthorship W2051283118A5000626384 @default.
• W2051283118 hasAuthorship W2051283118A5062461468 @default.
• W2051283118 hasConcept C104317684 @default.
• W2051283118 hasConcept C11960822 @default.
• W2051283118 hasConcept C12554922 @default.
• W2051283118 hasConcept C133571119 @default.
• W2051283118 hasConcept C143065580 @default.
• W2051283118 hasConcept C151730666 @default.
• W2051283118 hasConcept C178790620 @default.
• W2051283118 hasConcept C184538305 @default.
• W2051283118 hasConcept C185592680 @default.
• W2051283118 hasConcept C18903297 @default.
• W2051283118 hasConcept C204921945 @default.
• W2051283118 hasConcept C2776016237 @default.
• W2051283118 hasConcept C2776414213 @default.
• W2051283118 hasConcept C2778530040 @default.
• W2051283118 hasConcept C2779281246 @default.
• W2051283118 hasConcept C2779343474 @default.
• W2051283118 hasConcept C2779965526 @default.
• W2051283118 hasConcept C2780307904 @default.
• W2051283118 hasConcept C30765947 @default.
• W2051283118 hasConcept C515207424 @default.
• W2051283118 hasConcept C521977710 @default.
• W2051283118 hasConcept C55493867 @default.
• W2051283118 hasConcept C8010536 @default.
• W2051283118 hasConcept C86803240 @default.
• W2051283118 hasConceptScore W2051283118C104317684 @default.
• W2051283118 hasConceptScore W2051283118C11960822 @default.
• W2051283118 hasConceptScore W2051283118C12554922 @default.
• W2051283118 hasConceptScore W2051283118C133571119 @default.
• W2051283118 hasConceptScore W2051283118C143065580 @default.
• W2051283118 hasConceptScore W2051283118C151730666 @default.
• W2051283118 hasConceptScore W2051283118C178790620 @default.
• W2051283118 hasConceptScore W2051283118C184538305 @default.
• W2051283118 hasConceptScore W2051283118C185592680 @default.
• W2051283118 hasConceptScore W2051283118C18903297 @default.
• W2051283118 hasConceptScore W2051283118C204921945 @default.
• W2051283118 hasConceptScore W2051283118C2776016237 @default.
• W2051283118 hasConceptScore W2051283118C2776414213 @default.
• W2051283118 hasConceptScore W2051283118C2778530040 @default.
• W2051283118 hasConceptScore W2051283118C2779281246 @default.
• W2051283118 hasConceptScore W2051283118C2779343474 @default.
• W2051283118 hasConceptScore W2051283118C2779965526 @default.
• W2051283118 hasConceptScore W2051283118C2780307904 @default.
• W2051283118 hasConceptScore W2051283118C30765947 @default.
• W2051283118 hasConceptScore W2051283118C515207424 @default.
• W2051283118 hasConceptScore W2051283118C521977710 @default.
• W2051283118 hasConceptScore W2051283118C55493867 @default.
• W2051283118 hasConceptScore W2051283118C8010536 @default.
• W2051283118 hasConceptScore W2051283118C86803240 @default.
• W2051283118 hasIssue "20" @default.
• W2051283118 hasLocation W20512831181 @default.
• W2051283118 hasLocation W20512831182 @default.
• W2051283118 hasOpenAccess W2051283118 @default.
• W2051283118 hasPrimaryLocation W20512831181 @default.
• W2051283118 hasRelatedWork W1495784334 @default.
• W2051283118 hasRelatedWork W1987624211 @default.
• W2051283118 hasRelatedWork W2032222147 @default.
• W2051283118 hasRelatedWork W2038551902 @default.

• next