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- W2051283908 abstract "The growth-cone plasma membrane constantly reconfigures during axon navigation and upon target recognition. The identity and regulation of the membrane pathway(s) participating in remodeling of the growth-cone surface remain elusive. Here, we identify a constitutive, high-capacity plasma-membrane-recycling activity in the axonal growth cones, which is mediated by a novel bulk endocytic pathway that is mechanistically related to macropinocytosis. This pathway generates large compartments at sites of intense actin-based membrane ruffling through the actions of phosphatidylinositol 3-kinase, the small GTPase Rac1 and the pinocytic chaperone Pincher. At early developmental stages, bulk endocytosis is the primary endocytic pathway for rapid retrieval of the growth-cone plasma membrane. At later stages, during the onset of synaptogenesis, an intrinsic program of maturation leads to downregulation of basal bulk endocytosis and the emergence of depolarization-induced synaptic-vesicle exo-endocytosis. We propose that the control of bulk membrane retrieval contributes to the homeostatic regulation of the axonal plasma membrane and to growth-cone remodeling during axonal outgrowth. In addition, we suggest that the downregulation of bulk endocytosis during synaptogenesis might contribute to the preservation of synaptic-vesicle specificity." @default.
- W2051283908 created "2016-06-24" @default.
- W2051283908 creator A5003742541 @default.
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- W2051283908 date "2008-11-15" @default.
- W2051283908 modified "2023-09-28" @default.
- W2051283908 title "Identification of a developmentally regulated pathway of membrane retrieval in neuronal growth cones" @default.
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- W2051283908 doi "https://doi.org/10.1242/jcs.033803" @default.
- W2051283908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2731302" @default.
- W2051283908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18940911" @default.
- W2051283908 hasPublicationYear "2008" @default.
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