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- W2051284207 abstract "Twenty-three patients with chronic respiratory failure and 30 normal subjects were studied to assess the sympathetic nervous activity in chronic hypoxic states, especially in chronic cor pulmonale. Of the 23 patients, 13 had a right ventricular hypertrophy (RVH) pattern on the electrocardiogram. Plasma norepinephrine (NE), dopamine-β-hydroxylase (DBH), cyclic adenosine 3', 5'-monophosphate (cyclic AMP) and cyclic guanosine 3', 5'-monophosphate (cyclic GMP) concentrations were measured before and after oxygen inhalation. Plasma NE concentrations were 0.57 ± 0.07 ng/ml in patients with chronic respiratory failure and 0.22 ± 0.02 ng/ml in controls (p<0.001). Moreover, plasma NE concentrations were higher in patients with RVH than without (p<0.05), and these concentrations decreased significantly (p<0.05) in the former patients after oxygen inhalation. Plasma cyclic AMP concentrations were 31.2 ± 2.6 pmol/ml in cases of chronic respiratory failure and 17.4 ± 0.7 pmol/ml in controls (p<0.001) with no difference in plasma cyclic GMP and DBH concentrations. These results suggest that a significant proportion of patients with chronic respiratory failure, especially with cor pulmonale, were in hyper-adrenergic states partially due to hypoxia." @default.
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- W2051284207 date "1981-01-01" @default.
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- W2051284207 title "Sympathetic nervous systems in chronic cor pulmonale." @default.
- W2051284207 doi "https://doi.org/10.1253/jcj.45.646" @default.
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