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• W2051285690 abstract "Endometrial epithelial cells express HLA-DR molecules of the major histocompatibility complex in vivo adjacent to aggregates of T-cells in the endometrial stroma. To test whether HLA-DR expression on endometrial epithelium is mediated by T-cells, endometrial T-cells were isolated from human endometrium by the sheep red blood cell rosetting technique. In contrast to the resting T-cells from peripheral blood and similar to the peripheral blood T-cells activated with Conconavalin-A, endometrial T-cells formed colonies in vitro. Direct addition of the endometrial T-cells to epithelial cell cultures derived from autologous glands induced both morphological changes as well as HLA-DR molecules in the epithelial cells. The intensity of the immunostained HLA-DR molecules in the epithelial cells as well as the percentages of the HLA-DR-positive epithelial cells correlated with the number of T-cells added to the epithelial cell cultures. T-Cells were bound to the HLA-DR-positive epithelial cells as single cells or aggregates, and they were not found bound to the HLA-DR-negative epithelial cells. The supernatant of the endometrial T-cells induced expression of HLA-DR molecules and morphological changes in cultures of HLA-DR-negative epithelial cells. This expression could be inhibited by a neutralizing antiserum to interferon-7. These findings are consistent with the hypothesis that endometrial T-cells are activated and suggest that the expression of HLA-DR molecules in glandular epithelium in vivo is mediated by the interferon-γ secreted by the endometrial T-cells." @default.
• W2051285690 created "2016-06-24" @default.
• W2051285690 creator A5066021383 @default.
• W2051285690 date "1991-12-01" @default.
• W2051285690 modified "2023-09-27" @default.
• W2051285690 title "Induction of HLA-DR Expression in Endometrial Epithelial Cells by Endometrial T-Cells: Potential Regulatory Role of Endometrial T-Cells<i>in Vivo</i>" @default.
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• W2051285690 doi "https://doi.org/10.1210/jcem-73-6-1352" @default.
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