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- W2051286021 abstract "Background: The aim of this study was to explore the effect of popsickle with strawberry aroma on the infusion-related toxicity of cryopreserved autologous peripheral blood stem cells (PBSC). Methods: We compared two groups of adult patients receiving popsickle with strawberry aroma during infusion or not to assess the incidences of adverse events occurring during infusion. All patients received granisetron 2 × 3 mg iv, lorezepam 6 × 1 mg po for prophylaxis of the nausea and vomiting during conditioning phase and infusion day. The patients had no evidence of nausea or vomiting prior to cryopreserved PBSC infusion. The patients with ongoing nausea or vomiting owing to conditioning regimens and/or receiving additional anti-emetics were excluded from the study. Results: Forty-five patients (median age 45, range; 17–75) were given popsickle with strawberry aroma during infusion and 110 (median age, 42, range; 18–75) were not. The two groups were comparable with respect to age, gender, diagnosis, conditioning regimens, number of TNCs infused, number of bags infused, total volume infused, amount of DMSO and infusion rate. Patients receiving popsickle with strawberry aroma had significantly less nausea (21.8% vs 6.6%, p = 0.03) and had a trend for less vomiting (13.6% vs 4.4%, p = 0.1). Other infusion-related adverse events were as follows; abdominal cramping, tachycardia, hypertension, hypotension, chills, fever, sore throat and dyspnea. Incidences of each of these adverse events were less than 3% in both groups and were comparable. Conclusions: The use of popsickle with strawberry aroma during infusion of cryopreserved autologous PBSCs significantly decreases infusion-related nausea, decreases vomiting and recommended in this setting." @default.
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- W2051286021 date "2008-02-01" @default.
- W2051286021 modified "2023-09-26" @default.
- W2051286021 title "264: The Popsickle with Strawberry Aroma Reduces Infusion-Related Nausea and Vomiting During the Infusion of Cryopreserved Peripheral Blood Stem Cells" @default.
- W2051286021 doi "https://doi.org/10.1016/j.bbmt.2007.12.273" @default.
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