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• W2051286130 startingPage "3673" @default.
• W2051286130 abstract "The mechanisms by which beta1 integrins modulate T cell functions are still poorly defined. We have previously reported that signaling via the collagen type I (Coll I) receptor, alpha2beta1 integrin, inhibited FasL expression and protected Jurkat T cells from activation-induced cell death (AICD). In this study, we examined whether Coll I signaling in T cells also modulates the expression of the human receptor activator of nuclear factor-kappaB ligand (RANKL), a recently identified TNF family member which has important functions in osteoclastogenesis, cell survival and apoptosis. Our results show that in both Jurkat T cells and human primary T cells, Coll I signaling significantly reduces activation-induced RANKL expression by 50-60%. We also found that RANKL is not involved in AICD but participates in doxorubicin-induced apoptosis of leukemia T cell lines including Jurkat, CEM and HSB-2. In this respect, Coll I protected leukemia T cell lines from doxorubicin-induced apoptosis by inhibiting doxorubicin-induced RANKL expression. Together, our results suggest that by limiting the production of RANKL, Coll I signaling may contribute to the resistance of leukemia T cells to chemotherapy. Our study also emphasizes the importance Coll I signaling may have in the control of RANKL-associated T cell functions." @default.
• W2051286130 created "2016-06-24" @default.
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• W2051286130 creator A5060187188 @default.
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• W2051286130 date "2005-12-01" @default.
• W2051286130 modified "2023-09-27" @default.
• W2051286130 title "Collagen type I signaling reduces the expression and the function of human receptor activator of nuclear factor -κB ligand (RANKL) in T lymphocytes" @default.
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• W2051286130 doi "https://doi.org/10.1002/eji.200535065" @default.
• W2051286130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16304637" @default.
• W2051286130 hasPublicationYear "2005" @default.
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