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- W2051286239 abstract "The Shc adaptor protein, particularly its p52 isoform, has been identified as a primary signaling partner for the tyrosine(s)-phosphorylated cytoplasmic tails of activated β3 integrins. Inspired by our recent structure of the Shc PTB domain in complex with a bi-phosphorylated peptide derived from β3 cytoplasmic tail, we have initiated the investigation of Shc interaction with phospholipids of the membrane. We are particularly focused on PtdIns and their effects on Shc mediated integrin signaling in vitro. Here we present thermodynamic profiles and molecular details of the interactions between Shc, integrin, and PtdIns, all of which have been studied by ITC and solution NMR methods. A model of p52 Shc interaction with phosphorylated β3 integrin cytoplasmic tail at the cytosolic face of the plasma membrane is proposed based on these data." @default.
- W2051286239 created "2016-06-24" @default.
- W2051286239 creator A5013423438 @default.
- W2051286239 creator A5088558512 @default.
- W2051286239 date "2015-01-01" @default.
- W2051286239 modified "2023-10-16" @default.
- W2051286239 title "Phospho-Tyrosine(s) vs. Phosphatidylinositol Binding in Shc Mediated Integrin Signaling" @default.
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- W2051286239 doi "https://doi.org/10.4236/ajmb.2015.52003" @default.
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