Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051287156> ?p ?o ?g. }
- W2051287156 endingPage "565" @default.
- W2051287156 startingPage "551" @default.
- W2051287156 abstract "The molecular events that modulate chromatin structure during skeletal muscle differentiation are still poorly understood. We report in this paper that expression of the H3-K4 histone methyltransferase Set7 is increased when myoblasts differentiate into myotubes and is required for skeletal muscle development, expression of muscle contractile proteins, and myofibril assembly. Knockdown of Set7 or expression of a dominant-negative Set7 mutant impairs skeletal muscle differentiation, accompanied by a decrease in levels of histone monomethylation (H3-K4me1). Set7 directly interacts with MyoD to enhance expression of muscle differentiation genes. Expression of myocyte enhancer factor 2 and genes encoding contractile proteins is decreased in Set7 knockdown myocytes. Furthermore, we demonstrate that Set7 also activates muscle gene expression by precluding Suv39h1-mediated H3-K9 methylation on the promoters of myogenic differentiation genes. Together, our experiments define a biological function for Set7 in muscle differentiation and provide a molecular mechanism by which Set7 modulates myogenic transcription factors during muscle differentiation." @default.
- W2051287156 created "2016-06-24" @default.
- W2051287156 creator A5006328141 @default.
- W2051287156 creator A5028304434 @default.
- W2051287156 creator A5047043019 @default.
- W2051287156 creator A5068952870 @default.
- W2051287156 creator A5070370956 @default.
- W2051287156 creator A5074041207 @default.
- W2051287156 creator A5077161977 @default.
- W2051287156 creator A5089267785 @default.
- W2051287156 creator A5091846063 @default.
- W2051287156 date "2011-08-22" @default.
- W2051287156 modified "2023-10-16" @default.
- W2051287156 title "The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly" @default.
- W2051287156 cites W1969655939 @default.
- W2051287156 cites W1970461933 @default.
- W2051287156 cites W1972984824 @default.
- W2051287156 cites W1979187818 @default.
- W2051287156 cites W1980811848 @default.
- W2051287156 cites W1985061074 @default.
- W2051287156 cites W1985607497 @default.
- W2051287156 cites W1986903527 @default.
- W2051287156 cites W1989705133 @default.
- W2051287156 cites W1992868516 @default.
- W2051287156 cites W1993105398 @default.
- W2051287156 cites W1996015314 @default.
- W2051287156 cites W2003708679 @default.
- W2051287156 cites W2006305989 @default.
- W2051287156 cites W2006594553 @default.
- W2051287156 cites W2011824912 @default.
- W2051287156 cites W2013898345 @default.
- W2051287156 cites W2015416439 @default.
- W2051287156 cites W2019222060 @default.
- W2051287156 cites W2032858763 @default.
- W2051287156 cites W2035726606 @default.
- W2051287156 cites W2036676672 @default.
- W2051287156 cites W2062911743 @default.
- W2051287156 cites W2063982921 @default.
- W2051287156 cites W2064297857 @default.
- W2051287156 cites W2072387160 @default.
- W2051287156 cites W2078220845 @default.
- W2051287156 cites W2081091627 @default.
- W2051287156 cites W2081544530 @default.
- W2051287156 cites W2083441653 @default.
- W2051287156 cites W2100195805 @default.
- W2051287156 cites W2103735500 @default.
- W2051287156 cites W2108136318 @default.
- W2051287156 cites W2114395071 @default.
- W2051287156 cites W2116818563 @default.
- W2051287156 cites W2120594989 @default.
- W2051287156 cites W2123001330 @default.
- W2051287156 cites W2125295969 @default.
- W2051287156 cites W2129098267 @default.
- W2051287156 cites W2133919886 @default.
- W2051287156 cites W2134253526 @default.
- W2051287156 cites W2144806790 @default.
- W2051287156 cites W2163698312 @default.
- W2051287156 cites W2170891570 @default.
- W2051287156 doi "https://doi.org/10.1083/jcb.201010090" @default.
- W2051287156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3160588" @default.
- W2051287156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21859860" @default.
- W2051287156 hasPublicationYear "2011" @default.
- W2051287156 type Work @default.
- W2051287156 sameAs 2051287156 @default.
- W2051287156 citedByCount "102" @default.
- W2051287156 countsByYear W20512871562012 @default.
- W2051287156 countsByYear W20512871562013 @default.
- W2051287156 countsByYear W20512871562014 @default.
- W2051287156 countsByYear W20512871562015 @default.
- W2051287156 countsByYear W20512871562016 @default.
- W2051287156 countsByYear W20512871562017 @default.
- W2051287156 countsByYear W20512871562018 @default.
- W2051287156 countsByYear W20512871562019 @default.
- W2051287156 countsByYear W20512871562020 @default.
- W2051287156 countsByYear W20512871562021 @default.
- W2051287156 countsByYear W20512871562022 @default.
- W2051287156 countsByYear W20512871562023 @default.
- W2051287156 crossrefType "journal-article" @default.
- W2051287156 hasAuthorship W2051287156A5006328141 @default.
- W2051287156 hasAuthorship W2051287156A5028304434 @default.
- W2051287156 hasAuthorship W2051287156A5047043019 @default.
- W2051287156 hasAuthorship W2051287156A5068952870 @default.
- W2051287156 hasAuthorship W2051287156A5070370956 @default.
- W2051287156 hasAuthorship W2051287156A5074041207 @default.
- W2051287156 hasAuthorship W2051287156A5077161977 @default.
- W2051287156 hasAuthorship W2051287156A5089267785 @default.
- W2051287156 hasAuthorship W2051287156A5091846063 @default.
- W2051287156 hasBestOaLocation W20512871561 @default.
- W2051287156 hasConcept C101762097 @default.
- W2051287156 hasConcept C104317684 @default.
- W2051287156 hasConcept C111936080 @default.
- W2051287156 hasConcept C134018914 @default.
- W2051287156 hasConcept C134320426 @default.
- W2051287156 hasConcept C148738053 @default.
- W2051287156 hasConcept C150194340 @default.
- W2051287156 hasConcept C150425827 @default.
- W2051287156 hasConcept C173396325 @default.
- W2051287156 hasConcept C207200792 @default.