FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051287293> ?p ?o ?g. }

• W2051287293 endingPage "342" @default.
• W2051287293 startingPage "331" @default.
• W2051287293 abstract "The in vitro metabolism of [14C]methoxychlor (MXC), a suspected pro-oestrogenic compound, by male and female Fischer rats (F344) was compared in precision-cut liver slices. The results demonstrated time-dependent metabolism of MXC with integrated phase I and II reactions, and the sex differences were detected in the metabolic profiles. In liver slices from male rats, MXC was metabolized to bis-demethylated MXC (bis-OH-MXC) by sequential O-demethylation followed by subsequent O-glucuronidation. The doubly conjugated metabolite, bis-OH-MXC 4-O-sulphate 4′-O-glucuronide was additionally produced. In the case of the female rat, the glucuronides of both mono- and bis-OH-MXC were formed as the main metabolites, and the mono-OH-MXC glucuronide appeared to be specific to the female rat. The ratios of bis-/mono-demethylated metabolite, which include the amounts of corresponding conjugates, were approximately 95/5 for the male rats and 40/60 for the female. These results imply that demethylation to the intermediate metabolite, (S)-mono-OH-MXC, is a key step for the sex-dependent metabolism of MXC in the rats. The phase I metabolites produced were extensively conjugated with D-glucuronic acid in both male and female rats." @default.
• W2051287293 created "2016-06-24" @default.
• W2051287293 creator A5024350017 @default.
• W2051287293 creator A5070665337 @default.
• W2051287293 creator A5077180275 @default.
• W2051287293 creator A5089114137 @default.
• W2051287293 date "2005-04-01" @default.
• W2051287293 modified "2023-10-14" @default.
• W2051287293 title "Comparative<i>in vitro</i>metabolism of the suspected pro-oestrogenic compound, methoxychlor in precision-cut liver slices from male and female rats" @default.
• W2051287293 cites W10227885 @default.
• W2051287293 cites W1969560937 @default.
• W2051287293 cites W1989167667 @default.
• W2051287293 cites W2001201076 @default.
• W2051287293 cites W2034706088 @default.
• W2051287293 cites W2043390805 @default.
• W2051287293 cites W2050216144 @default.
• W2051287293 cites W2054099836 @default.
• W2051287293 cites W2054860008 @default.
• W2051287293 cites W2063378077 @default.
• W2051287293 cites W2067806189 @default.
• W2051287293 cites W2076156119 @default.
• W2051287293 cites W2089409885 @default.
• W2051287293 cites W2092435827 @default.
• W2051287293 cites W2094827480 @default.
• W2051287293 cites W2111364385 @default.
• W2051287293 cites W2111854122 @default.
• W2051287293 cites W2118359480 @default.
• W2051287293 cites W2125177126 @default.
• W2051287293 cites W2128487994 @default.
• W2051287293 cites W2168239129 @default.
• W2051287293 cites W2316373240 @default.
• W2051287293 cites W4255424346 @default.
• W2051287293 cites W4293247451 @default.
• W2051287293 cites W4297632282 @default.
• W2051287293 doi "https://doi.org/10.1080/00498250500087309" @default.
• W2051287293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16019955" @default.
• W2051287293 hasPublicationYear "2005" @default.
• W2051287293 type Work @default.
• W2051287293 sameAs 2051287293 @default.
• W2051287293 citedByCount "6" @default.
• W2051287293 countsByYear W20512872932013 @default.
• W2051287293 countsByYear W20512872932022 @default.
• W2051287293 crossrefType "journal-article" @default.
• W2051287293 hasAuthorship W2051287293A5024350017 @default.
• W2051287293 hasAuthorship W2051287293A5070665337 @default.
• W2051287293 hasAuthorship W2051287293A5077180275 @default.
• W2051287293 hasAuthorship W2051287293A5089114137 @default.
• W2051287293 hasConcept C104317684 @default.
• W2051287293 hasConcept C126322002 @default.
• W2051287293 hasConcept C134018914 @default.
• W2051287293 hasConcept C150194340 @default.
• W2051287293 hasConcept C161176658 @default.
• W2051287293 hasConcept C185592680 @default.
• W2051287293 hasConcept C190727270 @default.
• W2051287293 hasConcept C202199734 @default.
• W2051287293 hasConcept C202751555 @default.
• W2051287293 hasConcept C2776200302 @default.
• W2051287293 hasConcept C2777477808 @default.
• W2051287293 hasConcept C2779186261 @default.
• W2051287293 hasConcept C2779907587 @default.
• W2051287293 hasConcept C2780509179 @default.
• W2051287293 hasConcept C55493867 @default.
• W2051287293 hasConcept C62231903 @default.
• W2051287293 hasConcept C6557445 @default.
• W2051287293 hasConcept C71924100 @default.
• W2051287293 hasConcept C86803240 @default.
• W2051287293 hasConcept C87644729 @default.
• W2051287293 hasConceptScore W2051287293C104317684 @default.
• W2051287293 hasConceptScore W2051287293C126322002 @default.
• W2051287293 hasConceptScore W2051287293C134018914 @default.
• W2051287293 hasConceptScore W2051287293C150194340 @default.
• W2051287293 hasConceptScore W2051287293C161176658 @default.
• W2051287293 hasConceptScore W2051287293C185592680 @default.
• W2051287293 hasConceptScore W2051287293C190727270 @default.
• W2051287293 hasConceptScore W2051287293C202199734 @default.
• W2051287293 hasConceptScore W2051287293C202751555 @default.
• W2051287293 hasConceptScore W2051287293C2776200302 @default.
• W2051287293 hasConceptScore W2051287293C2777477808 @default.
• W2051287293 hasConceptScore W2051287293C2779186261 @default.
• W2051287293 hasConceptScore W2051287293C2779907587 @default.
• W2051287293 hasConceptScore W2051287293C2780509179 @default.
• W2051287293 hasConceptScore W2051287293C55493867 @default.
• W2051287293 hasConceptScore W2051287293C62231903 @default.
• W2051287293 hasConceptScore W2051287293C6557445 @default.
• W2051287293 hasConceptScore W2051287293C71924100 @default.
• W2051287293 hasConceptScore W2051287293C86803240 @default.
• W2051287293 hasConceptScore W2051287293C87644729 @default.
• W2051287293 hasIssue "4" @default.
• W2051287293 hasLocation W20512872931 @default.
• W2051287293 hasLocation W20512872932 @default.
• W2051287293 hasOpenAccess W2051287293 @default.
• W2051287293 hasPrimaryLocation W20512872931 @default.
• W2051287293 hasRelatedWork W1851873892 @default.
• W2051287293 hasRelatedWork W2040074963 @default.
• W2051287293 hasRelatedWork W2051287293 @default.
• W2051287293 hasRelatedWork W2062195390 @default.
• W2051287293 hasRelatedWork W2090888544 @default.
• W2051287293 hasRelatedWork W2112091313 @default.

• next