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- W2051288524 abstract "1. The cimetidine-nicoumalone interaction was studied in five subjects who received a single 10 mg oral dose of racemic nicoumalone alone and 3 days into an oral regimen of cimetidine of 200 mg three times daily and 400 mg at night. 2. The concentrations of R(+)- and S(−)− nicoumalone in plasma were measured using a stereospecific h.p.l.c assay; augmentation of prothrombin time was used as a measure of response. 3. Cimetidine increased the rate (but not extent) of absorption of both R(+)- and S(−)−nicoumalone, and reduced the clearance of R(+)-nicoumalone but not that of the S(−)−enantiomer. 4. Cimetidine increased the anticoagulant response produced by nicoumalone in some but not all subjects, despite a consistent effect on the pharmacokinetics of the oral anti-coagulant. 5. Cimetidine appears to produce its effect by stereoselectively inhibiting the elimination of R(+)-nicoumalone." @default.
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- W2051288524 date "1989-04-01" @default.
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- W2051288524 title "Cimetidine-nicoumalone interaction in man: stereochemical considerations." @default.
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- W2051288524 doi "https://doi.org/10.1111/j.1365-2125.1989.tb05395.x" @default.
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