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• W2051288540 abstract "Cantharidin is well known as a potent serine/threonine protein phosphatase 1 and 2A (PP1 and PP2A) inhibitor, with less potent inhibitory activity for PP2B, which regulates T-cell proliferation. We synthesized and evaluated four optically pure stereoisomers of 1-substituted norcantharidin analogues. The absolute stereochemistry of each stereoisomer was determined based on X-ray crystal structure analysis. Remarkably, optically active cantharidin analogues having (1S)-configuration showed selective inhibition of PP2B, without inhibiting PP1 or PP2A." @default.
• W2051288540 created "2016-06-24" @default.
• W2051288540 creator A5012532329 @default.
• W2051288540 creator A5028745236 @default.
• W2051288540 creator A5036299859 @default.
• W2051288540 date "2005-09-01" @default.
• W2051288540 modified "2023-10-17" @default.
• W2051288540 title "Optically active cantharidin analogues possessing selective inhibitory activity on Ser/Thr protein phosphatase 2B (calcineurin): Implications for the binding mode" @default.
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• W2051288540 doi "https://doi.org/10.1016/j.bmc.2005.05.013" @default.
• W2051288540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15951185" @default.
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