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- W2051288760 abstract "This study evaluated contraception by formulated Ushercell™, a uniquely high-molecular-weight form of cellulose sulfate, in the rabbit. Variables included (1) dose effectiveness, (2) duration of effectiveness, and (3) formulation excipients. Vaginally applied carboxymethyl-cellulose-based Ushercell™ gel is contraceptive. A 6% gel is active for at least 18 h; partial activity is observed for at least 24 h. With an application–insemination interval of 0.5 h, Ushercell™ as low as 0.1% is contraceptive. Contraception is incomplete with 2% Ushercell™ and an application–insemination interval of 24 h. Ushercell™ formulations containing a relatively high concentration of Carbopol are ineffective contraceptives, whether the gel is applied before insemination or is premixed with spermatozoa before insemination. Contraceptive activity is restored in Ushercell™ formulations with lower Carbopol content. This study shows that formulated Ushercell™ is an effective, long-lasting contraceptive and, hence, is bioavailable when vaginally applied. Activity is dependent on the type and relative concentration of formulation excipients. These data support a projected successful outcome of further clinical trials." @default.
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- W2051288760 date "1954-01-01" @default.
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- W2051288760 title "Synthetic polyanionic inhibitors of hyaluronidase" @default.
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- W2051288760 doi "https://doi.org/10.1016/0006-3002(54)90319-4" @default.
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