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• W2051289332 abstract "In striatonigral projections activation of dopamine D3 receptors (D3Rs) potentiates the stimulation of GABA release and cAMP production caused by activation of dopamine D1 receptors (D1Rs). Cytoplasmic [Ca2 +] in the terminals controls this response by modulating CaMKII, an enzyme that depresses D3R action. To examine the effects of dopamine deprivation on D3R signaling we investigated their function in striatonigral terminals of hemiparkinsonian rats. Denervation switched the signaling cascade initiated by D3R activation. In the non-lesioned side activation of D3R potentiated the stimulatory effects of D1R activation on cAMP production and K+-depolarization induced [3H] GABA release. In contrast, in the denervated side the stimulatory effects of both D1R activation and forskolin administration were blocked by D3R activation. In non-lesioned slices, D3R responses were inhibited by the activation of CaMKII produced by K+-depolarization (via increased Ca2 + entry). The CaMKII-induced inhibition was blocked by the selective inhibitor KN-62. In denervated tissues the response to D3R stimulation was not modified either by K+ depolarization or by blocking CaMKII with KN-62. Immunoblotting studies showed that depolarization-induced CaMKII binding to the D3 receptor and CaMKII phosphorylation were suppressed in denervated tissues. We also determined calmodulin expression with PCR and immunoblot techniques. Both techniques showed that calmodulin expression was depressed in the lesioned side. In sum, our studies show that dopaminergic denervation switches the D3R signaling cascade and depresses CaMKII signaling through a process that appears to involve reduced calmodulin levels. Since calmodulin is a major cytoplasmic Ca2 + buffer our findings suggest that abnormal Ca2 + buffering may be an important component of the abnormalities observed during dopaminergic denervation." @default.
• W2051289332 created "2016-06-24" @default.
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• W2051289332 date "2015-02-01" @default.
• W2051289332 modified "2023-09-27" @default.
• W2051289332 title "Dopaminergic denervation switches dopamine D3 receptor signaling and disrupts its Ca2+ dependent modulation by CaMKII and calmodulin in striatonigral projections of the rat" @default.
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• W2051289332 doi "https://doi.org/10.1016/j.nbd.2014.12.008" @default.
• W2051289332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25517101" @default.
• W2051289332 hasPublicationYear "2015" @default.
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