FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051290209> ?p ?o ?g. }

• W2051290209 abstract "The etiology of a significant proportion of familial breast cancers is still poorly understood, with known high penetrance gene mutations accounting for only a small proportion of the cases. The increased risk of breast cancer for the majority of women with a family history likely reflects shared minor low penetrant genetic factors. In the present case-control study undertaken to examine the influence of DNA damage repair gene polymorphisms in familial and sporadic breast cancer susceptibility, 219 Sporadic and 140 familial breast cancer patients and 367 controls were genotyped using PCRRFLP. Odds Ratios (ORs) and 95% Confidence Intervals (95%CIs) were calculated by unconditional logistic regression adjusted to age. Variant genotypes XRCC1 Arg/Gln or Gln/Gln and XPD Lys/Gln or Gln/Gln increased both familial and sporadic breast cancer susceptibility. However, when the intra group risk was compared, the risk due to the XPD polymorphic genotypes Lys/Gln or Gln/Gln was significantly lower among familial breast cancer patients compared to sporadic breast cancer patients [OR = 0.61; 95%CI = 0.39-0.94; p value = 0.024) whereas the risk implied by XRCC1 variant genotype was not significantly different between the familial and nonfamilial groups of breast cancer patients [OR = 0.97; 95%CI = 0.63-1.49; p value = 0.882]. Both these variant genotypes were not associated with the disease characteristics or survival of either familial or sporadic breast cancer patients. This study represents an addition to previous published work on GSTs from the same study population and substantiates the hypothesis that the impact of the low penetrance gene polymorphisms differ by family history of the disease." @default.
• W2051290209 created "2016-06-24" @default.
• W2051290209 creator A5051356701 @default.
• W2051290209 creator A5051429729 @default.
• W2051290209 creator A5052152088 @default.
• W2051290209 creator A5056593854 @default.
• W2051290209 creator A5069952774 @default.
• W2051290209 creator A5075665709 @default.
• W2051290209 date "2008-12-04" @default.
• W2051290209 modified "2023-09-24" @default.
• W2051290209 title "Contribution of XPD (Lys751Gln) and XRCC1 (Arg399Gln) Polymorphisms in Familial and Sporadic Breast Cancer Predisposition and Survival: An Indian Report" @default.
• W2051290209 cites W1537739161 @default.
• W2051290209 cites W1893532594 @default.
• W2051290209 cites W1971517620 @default.
• W2051290209 cites W1974730203 @default.
• W2051290209 cites W1977439202 @default.
• W2051290209 cites W1977932650 @default.
• W2051290209 cites W1978264816 @default.
• W2051290209 cites W1983585864 @default.
• W2051290209 cites W1993147927 @default.
• W2051290209 cites W1995077573 @default.
• W2051290209 cites W2005634249 @default.
• W2051290209 cites W2006093482 @default.
• W2051290209 cites W2017161034 @default.
• W2051290209 cites W2022875409 @default.
• W2051290209 cites W2024526953 @default.
• W2051290209 cites W2051550942 @default.
• W2051290209 cites W2058141758 @default.
• W2051290209 cites W2062223676 @default.
• W2051290209 cites W2068176376 @default.
• W2051290209 cites W2089867989 @default.
• W2051290209 cites W2095033674 @default.
• W2051290209 cites W2104442957 @default.
• W2051290209 cites W2114969796 @default.
• W2051290209 cites W2115602884 @default.
• W2051290209 cites W2124459922 @default.
• W2051290209 cites W2128946284 @default.
• W2051290209 cites W2134358950 @default.
• W2051290209 cites W2136962577 @default.
• W2051290209 cites W2152914176 @default.
• W2051290209 cites W2161472724 @default.
• W2051290209 cites W2164416813 @default.
• W2051290209 cites W2168340452 @default.
• W2051290209 cites W2169554211 @default.
• W2051290209 cites W2170451160 @default.
• W2051290209 doi "https://doi.org/10.1007/s12253-008-9135-8" @default.
• W2051290209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19051060" @default.
• W2051290209 hasPublicationYear "2008" @default.
• W2051290209 type Work @default.
• W2051290209 sameAs 2051290209 @default.
• W2051290209 citedByCount "18" @default.
• W2051290209 countsByYear W20512902092013 @default.
• W2051290209 countsByYear W20512902092014 @default.
• W2051290209 countsByYear W20512902092015 @default.
• W2051290209 countsByYear W20512902092016 @default.
• W2051290209 countsByYear W20512902092017 @default.
• W2051290209 countsByYear W20512902092020 @default.
• W2051290209 crossrefType "journal-article" @default.
• W2051290209 hasAuthorship W2051290209A5051356701 @default.
• W2051290209 hasAuthorship W2051290209A5051429729 @default.
• W2051290209 hasAuthorship W2051290209A5052152088 @default.
• W2051290209 hasAuthorship W2051290209A5056593854 @default.
• W2051290209 hasAuthorship W2051290209A5069952774 @default.
• W2051290209 hasAuthorship W2051290209A5075665709 @default.
• W2051290209 hasConcept C104317684 @default.
• W2051290209 hasConcept C121608353 @default.
• W2051290209 hasConcept C126322002 @default.
• W2051290209 hasConcept C127716648 @default.
• W2051290209 hasConcept C135763542 @default.
• W2051290209 hasConcept C143998085 @default.
• W2051290209 hasConcept C153209595 @default.
• W2051290209 hasConcept C156957248 @default.
• W2051290209 hasConcept C200544954 @default.
• W2051290209 hasConcept C2776999993 @default.
• W2051290209 hasConcept C2779134260 @default.
• W2051290209 hasConcept C2781179581 @default.
• W2051290209 hasConcept C530470458 @default.
• W2051290209 hasConcept C54355233 @default.
• W2051290209 hasConcept C67636389 @default.
• W2051290209 hasConcept C71924100 @default.
• W2051290209 hasConcept C86803240 @default.
• W2051290209 hasConceptScore W2051290209C104317684 @default.
• W2051290209 hasConceptScore W2051290209C121608353 @default.
• W2051290209 hasConceptScore W2051290209C126322002 @default.
• W2051290209 hasConceptScore W2051290209C127716648 @default.
• W2051290209 hasConceptScore W2051290209C135763542 @default.
• W2051290209 hasConceptScore W2051290209C143998085 @default.
• W2051290209 hasConceptScore W2051290209C153209595 @default.
• W2051290209 hasConceptScore W2051290209C156957248 @default.
• W2051290209 hasConceptScore W2051290209C200544954 @default.
• W2051290209 hasConceptScore W2051290209C2776999993 @default.
• W2051290209 hasConceptScore W2051290209C2779134260 @default.
• W2051290209 hasConceptScore W2051290209C2781179581 @default.
• W2051290209 hasConceptScore W2051290209C530470458 @default.
• W2051290209 hasConceptScore W2051290209C54355233 @default.
• W2051290209 hasConceptScore W2051290209C67636389 @default.
• W2051290209 hasConceptScore W2051290209C71924100 @default.
• W2051290209 hasConceptScore W2051290209C86803240 @default.
• W2051290209 hasLocation W20512902091 @default.
• W2051290209 hasLocation W20512902092 @default.

• next