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- W2051293000 abstract "Abstract The ferrocenyl diphenol 1 [1,1‐bis(4‐hydroxyphenyl)‐2‐ferrocenyl‐but‐1‐ene] displays strong cytotoxic effects against a variety of cancer cells. In the present study we have evaluated the immunomodulatory and antiparasitic activities of compound 1 and its protected dipalmitate analogue 2. We have furthermore compared the antiparasitic results of 1 and 2 with the organic analogue, 3 [1,1‐bis(4‐hydroxyphenyl)‐2‐phenyl‐but‐1‐ene], where the ferrocenyl group has been replaced by a phenyl ring. When assayed against normal (noncancerous) splenocytes, all compounds were considered nontoxic. Compound 1 inhibited NO production by macrophages, inhibited concanavalin A‐induced lymphoproliferation, and was active against Leishmania amazonensis and Trypanosoma cruzi . Compound 2 had lower activity in all assays performed. Surprisingly, compounds 1 and 2 exhibited similar and significant activity against Plasmodium falciparum , with IC 50 values of 3.50 and 1.33 µM, respectively. Compound 3 showed an inverse activity profile, being active against T. cruzi but far less active against P. falciparum . Drug Dev Res 71: 69–75, 2010. © 2009 Wiley‐Liss, Inc." @default.
- W2051293000 created "2016-06-24" @default.
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- W2051293000 date "2009-12-09" @default.
- W2051293000 modified "2023-10-14" @default.
- W2051293000 title "Antiparasitic and immunomodulatory activities of 1,1-bis(4-hydroxyphenyl)-2-phenyl-but-1-ene and its protected and free 2-ferrocenyl derivatives" @default.
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- W2051293000 doi "https://doi.org/10.1002/ddr.20349" @default.
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