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- W2051294227 abstract "Tetrahymena cells grown on a rich growth medium may be starved for thymidine by addition of methotrexate plus uridine (M+U). The effect of this treatment on replicating DNA molecules and the fate of these molecules after release from the starvation condition have been studied. Thymidine starvation during the latter half of the macronuclear S-period leads to the appearance of a DNA fraction with a buoyant density higher than that of bulk DNA. In the next cell cycle, after removal of M+U by transfer of the cells to a fresh growth medium, this heavy DNA fraction persists throughout the macronuclear S-period, but it disappears during the following G2-period and is converted to a DNA fraction with relatively low buoyant density. Based on these results, it is suggested 1) that the thymidine starvation preferentially inhibits replication in regions of the DNA molecules with high dAdT base pair concentrations, 2) that the DNA molecules stalled in replication are partially single-stranded and 3) that the low buoyant density DNA fraction is formed as a consequence of a completion of these molecules to fully double-stranded DNA." @default.
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- W2051294227 date "1977-05-01" @default.
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- W2051294227 title "DNA replication in tetrahymena after release from thymidine starvation" @default.
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- W2051294227 doi "https://doi.org/10.1007/bf02910460" @default.
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