Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051295463> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2051295463 endingPage "280" @default.
- W2051295463 startingPage "275" @default.
- W2051295463 abstract "UCN-01 (7-hydroxystaurosporine) inhibits the growth of various malignant cell lines in vitro and in vivo. In this study, a human small cell lung carcinoma subline resistant to UCN-01, SBC-3/UCN, was established and characterized. SBC-3/UCN cells showed 8-fold greater resistance to the UCN-01-induced growth-inhibitory effect than the parent cells, SBC-3. No UCN-01-induced G1 accumulation in SBC-3 cells was observed in SBC-3/UCN cells and decreased expression of phosphorylated RB protein was found in SBC-3 cells. Neither basal expression nor induction of p21(Cip1) by UCN-01 treatment was detected in the SBC-3/UCN cell line. An inhibitory effect of UCN-01 on CDK2 activity, which is mediated by p21(Cip1)/CDK2 complex formation upon UCN-01 treatment, was observed in SBC-3 but not in SBC-3/UCN cells. SBC-3/UCN showed higher CDK6 activity than SBC-3 cells. UCN-01 did not inhibit the CDK4 and CDK6 activities in both cells. We screened the cell cycle regulatory molecules associated with G(1)/S progression and found a remarked decrease in interferon regulatory factor 1 (IRF-1), which is known to cooperate with p53 in p21(Cip1) induction. Our results suggest that p21(Cip1) regulation via the IRF-1-associated pathway may represent a major determinant of UCN-01-induced growth inhibition in human lung cancer cells." @default.
- W2051295463 created "2016-06-24" @default.
- W2051295463 creator A5001660113 @default.
- W2051295463 creator A5004282323 @default.
- W2051295463 creator A5009083727 @default.
- W2051295463 creator A5012518349 @default.
- W2051295463 creator A5037099107 @default.
- W2051295463 creator A5038813552 @default.
- W2051295463 creator A5044867185 @default.
- W2051295463 creator A5048801191 @default.
- W2051295463 creator A5050855780 @default.
- W2051295463 creator A5054386489 @default.
- W2051295463 creator A5058549884 @default.
- W2051295463 creator A5088875334 @default.
- W2051295463 date "2000-01-15" @default.
- W2051295463 modified "2023-09-27" @default.
- W2051295463 title "Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells" @default.
- W2051295463 cites W1969268496 @default.
- W2051295463 cites W1969355167 @default.
- W2051295463 cites W1991767510 @default.
- W2051295463 cites W2028297274 @default.
- W2051295463 cites W2039373918 @default.
- W2051295463 cites W2114918609 @default.
- W2051295463 doi "https://doi.org/10.1002/(sici)1097-0215(20000115)85:2<275::aid-ijc20>3.0.co;2-5" @default.
- W2051295463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10629089" @default.
- W2051295463 hasPublicationYear "2000" @default.
- W2051295463 type Work @default.
- W2051295463 sameAs 2051295463 @default.
- W2051295463 citedByCount "17" @default.
- W2051295463 countsByYear W20512954632013 @default.
- W2051295463 countsByYear W20512954632017 @default.
- W2051295463 crossrefType "journal-article" @default.
- W2051295463 hasAuthorship W2051295463A5001660113 @default.
- W2051295463 hasAuthorship W2051295463A5004282323 @default.
- W2051295463 hasAuthorship W2051295463A5009083727 @default.
- W2051295463 hasAuthorship W2051295463A5012518349 @default.
- W2051295463 hasAuthorship W2051295463A5037099107 @default.
- W2051295463 hasAuthorship W2051295463A5038813552 @default.
- W2051295463 hasAuthorship W2051295463A5044867185 @default.
- W2051295463 hasAuthorship W2051295463A5048801191 @default.
- W2051295463 hasAuthorship W2051295463A5050855780 @default.
- W2051295463 hasAuthorship W2051295463A5054386489 @default.
- W2051295463 hasAuthorship W2051295463A5058549884 @default.
- W2051295463 hasAuthorship W2051295463A5088875334 @default.
- W2051295463 hasConcept C126322002 @default.
- W2051295463 hasConcept C1491633281 @default.
- W2051295463 hasConcept C153911025 @default.
- W2051295463 hasConcept C185592680 @default.
- W2051295463 hasConcept C199649820 @default.
- W2051295463 hasConcept C207001950 @default.
- W2051295463 hasConcept C2779707156 @default.
- W2051295463 hasConcept C29537977 @default.
- W2051295463 hasConcept C502942594 @default.
- W2051295463 hasConcept C54355233 @default.
- W2051295463 hasConcept C55493867 @default.
- W2051295463 hasConcept C62112901 @default.
- W2051295463 hasConcept C71924100 @default.
- W2051295463 hasConcept C81885089 @default.
- W2051295463 hasConcept C82495950 @default.
- W2051295463 hasConcept C86803240 @default.
- W2051295463 hasConcept C95444343 @default.
- W2051295463 hasConceptScore W2051295463C126322002 @default.
- W2051295463 hasConceptScore W2051295463C1491633281 @default.
- W2051295463 hasConceptScore W2051295463C153911025 @default.
- W2051295463 hasConceptScore W2051295463C185592680 @default.
- W2051295463 hasConceptScore W2051295463C199649820 @default.
- W2051295463 hasConceptScore W2051295463C207001950 @default.
- W2051295463 hasConceptScore W2051295463C2779707156 @default.
- W2051295463 hasConceptScore W2051295463C29537977 @default.
- W2051295463 hasConceptScore W2051295463C502942594 @default.
- W2051295463 hasConceptScore W2051295463C54355233 @default.
- W2051295463 hasConceptScore W2051295463C55493867 @default.
- W2051295463 hasConceptScore W2051295463C62112901 @default.
- W2051295463 hasConceptScore W2051295463C71924100 @default.
- W2051295463 hasConceptScore W2051295463C81885089 @default.
- W2051295463 hasConceptScore W2051295463C82495950 @default.
- W2051295463 hasConceptScore W2051295463C86803240 @default.
- W2051295463 hasConceptScore W2051295463C95444343 @default.
- W2051295463 hasIssue "2" @default.
- W2051295463 hasLocation W20512954631 @default.
- W2051295463 hasLocation W20512954632 @default.
- W2051295463 hasOpenAccess W2051295463 @default.
- W2051295463 hasPrimaryLocation W20512954631 @default.
- W2051295463 hasRelatedWork W2008317297 @default.
- W2051295463 hasRelatedWork W2039171481 @default.
- W2051295463 hasRelatedWork W2066519212 @default.
- W2051295463 hasRelatedWork W2072481810 @default.
- W2051295463 hasRelatedWork W2361816167 @default.
- W2051295463 hasRelatedWork W2373495330 @default.
- W2051295463 hasRelatedWork W2374592133 @default.
- W2051295463 hasRelatedWork W2376385662 @default.
- W2051295463 hasRelatedWork W2387175565 @default.
- W2051295463 hasRelatedWork W2608904130 @default.
- W2051295463 hasVolume "85" @default.
- W2051295463 isParatext "false" @default.
- W2051295463 isRetracted "false" @default.
- W2051295463 magId "2051295463" @default.
- W2051295463 workType "article" @default.