Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051295676> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2051295676 endingPage "22" @default.
- W2051295676 startingPage "15" @default.
- W2051295676 abstract "Lung cancer is not one disease but many diseases with specific molecular profiles and treatment alternatives. EGF receptor-activating mutations predict a high, albeit short-lived, response to reversible tyrosine kinase inhibitors (e.g., gefitinib and erlotinib). Acquired resistance mutations can result in tumor progression. Dual EGFR/HER2 irreversible inhibitors are small novel molecules that can overcome gefitinib/erlotinib resistance by potentially circumventing multiple mechanisms of acquired resistance, as shown in vitro. Afatinib is an irreversible inhibitor with potent phosphorylation inhibitory activity of both EGF receptor and HER2. Durable responses were observed in Phase I trials in advanced non-small-cell lung cancer at 50 mg once daily. In Phase II trials, reduction in tumor size was observed in 90% of patients. The objective response and disease control rate were 62 and 94%, respectively. Median progression-free survival was estimated at 12 months (95% CI: 10.0–19.2). The most common drug-rel..." @default.
- W2051295676 created "2016-06-24" @default.
- W2051295676 creator A5062558399 @default.
- W2051295676 date "2011-01-01" @default.
- W2051295676 modified "2023-09-26" @default.
- W2051295676 title "Afatinib (BIBW-2992): a novel dual EGFR/HER2neu inhibitor with promising activity in non-small-cell lung cancer" @default.
- W2051295676 cites W1482218984 @default.
- W2051295676 cites W1992308894 @default.
- W2051295676 cites W1998971866 @default.
- W2051295676 cites W2002937040 @default.
- W2051295676 cites W2007528734 @default.
- W2051295676 cites W2010163679 @default.
- W2051295676 cites W2016710415 @default.
- W2051295676 cites W2021312892 @default.
- W2051295676 cites W2033771482 @default.
- W2051295676 cites W2037873277 @default.
- W2051295676 cites W2043103956 @default.
- W2051295676 cites W2043696829 @default.
- W2051295676 cites W2050156776 @default.
- W2051295676 cites W2063391304 @default.
- W2051295676 cites W2095618958 @default.
- W2051295676 cites W2101329867 @default.
- W2051295676 cites W2103894337 @default.
- W2051295676 cites W2109080255 @default.
- W2051295676 cites W2114095518 @default.
- W2051295676 cites W2114195503 @default.
- W2051295676 cites W2120718661 @default.
- W2051295676 cites W2121389354 @default.
- W2051295676 cites W2125589729 @default.
- W2051295676 cites W2129360604 @default.
- W2051295676 cites W2132157071 @default.
- W2051295676 cites W2132337295 @default.
- W2051295676 cites W2139236349 @default.
- W2051295676 cites W2153156618 @default.
- W2051295676 cites W2161821474 @default.
- W2051295676 cites W2168554121 @default.
- W2051295676 cites W2168841302 @default.
- W2051295676 cites W2169816570 @default.
- W2051295676 cites W2425385554 @default.
- W2051295676 cites W4246392208 @default.
- W2051295676 doi "https://doi.org/10.2217/thy.10.86" @default.
- W2051295676 hasPublicationYear "2011" @default.
- W2051295676 type Work @default.
- W2051295676 sameAs 2051295676 @default.
- W2051295676 citedByCount "6" @default.
- W2051295676 countsByYear W20512956762013 @default.
- W2051295676 countsByYear W20512956762014 @default.
- W2051295676 countsByYear W20512956762015 @default.
- W2051295676 countsByYear W20512956762017 @default.
- W2051295676 countsByYear W20512956762019 @default.
- W2051295676 crossrefType "journal-article" @default.
- W2051295676 hasAuthorship W2051295676A5062558399 @default.
- W2051295676 hasBestOaLocation W20512956762 @default.
- W2051295676 hasConcept C121608353 @default.
- W2051295676 hasConcept C126322002 @default.
- W2051295676 hasConcept C143998085 @default.
- W2051295676 hasConcept C2776256026 @default.
- W2051295676 hasConcept C2779438470 @default.
- W2051295676 hasConcept C2780580887 @default.
- W2051295676 hasConcept C2780586478 @default.
- W2051295676 hasConcept C71924100 @default.
- W2051295676 hasConcept C98274493 @default.
- W2051295676 hasConceptScore W2051295676C121608353 @default.
- W2051295676 hasConceptScore W2051295676C126322002 @default.
- W2051295676 hasConceptScore W2051295676C143998085 @default.
- W2051295676 hasConceptScore W2051295676C2776256026 @default.
- W2051295676 hasConceptScore W2051295676C2779438470 @default.
- W2051295676 hasConceptScore W2051295676C2780580887 @default.
- W2051295676 hasConceptScore W2051295676C2780586478 @default.
- W2051295676 hasConceptScore W2051295676C71924100 @default.
- W2051295676 hasConceptScore W2051295676C98274493 @default.
- W2051295676 hasIssue "1" @default.
- W2051295676 hasLocation W20512956761 @default.
- W2051295676 hasLocation W20512956762 @default.
- W2051295676 hasOpenAccess W2051295676 @default.
- W2051295676 hasPrimaryLocation W20512956761 @default.
- W2051295676 hasRelatedWork W1967103478 @default.
- W2051295676 hasRelatedWork W2372561159 @default.
- W2051295676 hasRelatedWork W2375344515 @default.
- W2051295676 hasRelatedWork W2380382254 @default.
- W2051295676 hasRelatedWork W2390152934 @default.
- W2051295676 hasRelatedWork W2412727163 @default.
- W2051295676 hasRelatedWork W3035002194 @default.
- W2051295676 hasRelatedWork W4200207786 @default.
- W2051295676 hasRelatedWork W4210598365 @default.
- W2051295676 hasRelatedWork W4224237029 @default.
- W2051295676 hasVolume "8" @default.
- W2051295676 isParatext "false" @default.
- W2051295676 isRetracted "false" @default.
- W2051295676 magId "2051295676" @default.
- W2051295676 workType "article" @default.