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• W2051296133 abstract "Natural killer (NK) cells contribute to the essential functions of innate immunity and reproduction. Various genes encode NK cell receptors that recognize the major histocompatibility complex (MHC) Class I molecules expressed by other cells. For primate NK cells, the killer-cell immunoglobulin-like receptors (KIR) are a variable and rapidly evolving family of MHC Class I receptors. Studied here is KIR3DL1/S1, which encodes receptors for highly polymorphic human HLA-A and -B and comprises three ancient allelic lineages that have been preserved by balancing selection throughout human evolution. While the 3DS1 lineage of activating receptors has been conserved, the two 3DL1 lineages of inhibitory receptors were diversified through inter-lineage recombination with each other and with 3DS1. Prominent targets for recombination were D0-domain polymorphisms, which modulate enhancer function, and dimorphism at position 283 in the D2 domain, which influences inhibitory function. In African populations, unequal crossing over between the 3DL1 and 3DL2 genes produced a deleted KIR haplotype in which the telomeric half was reduced to a single fusion gene with functional properties distinct from its 3DL1 and 3DL2 parents. Conversely, in Eurasian populations, duplication of the KIR3DL1/S1 locus by unequal crossing over has enabled individuals to carry and express alleles of all three KIR3DL1/S1 lineages. These results demonstrate how meiotic recombination combines with an ancient, preserved diversity to create new KIR phenotypes upon which natural selection acts. A consequence of such recombination is to blur the distinction between alleles and loci in the rapidly evolving human KIR gene family." @default.
• W2051296133 created "2016-06-24" @default.
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• W2051296133 date "2009-05-01" @default.
• W2051296133 modified "2023-10-17" @default.
• W2051296133 title "Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes" @default.
• W2051296133 cites W1481223393 @default.
• W2051296133 cites W1481510475 @default.
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• W2051296133 cites W1524049020 @default.
• W2051296133 cites W1552389130 @default.
• W2051296133 cites W1574784499 @default.
• W2051296133 cites W1623632976 @default.
• W2051296133 cites W1634636209 @default.
• W2051296133 cites W1664548846 @default.
• W2051296133 cites W1756638473 @default.
• W2051296133 cites W1764663529 @default.
• W2051296133 cites W1830462044 @default.
• W2051296133 cites W1876767059 @default.
• W2051296133 cites W1911209830 @default.
• W2051296133 cites W1965463920 @default.
• W2051296133 cites W1967773296 @default.
• W2051296133 cites W1968002146 @default.
• W2051296133 cites W1968046203 @default.
• W2051296133 cites W1968529138 @default.
• W2051296133 cites W1973220478 @default.
• W2051296133 cites W1988875184 @default.
• W2051296133 cites W1994057432 @default.
• W2051296133 cites W2001972055 @default.
• W2051296133 cites W2003890249 @default.
• W2051296133 cites W2008919922 @default.
• W2051296133 cites W2009454818 @default.
• W2051296133 cites W2011017810 @default.
• W2051296133 cites W2023394414 @default.
• W2051296133 cites W2028369131 @default.
• W2051296133 cites W2031560373 @default.
• W2051296133 cites W2032292023 @default.
• W2051296133 cites W2036334598 @default.
• W2051296133 cites W2043993805 @default.
• W2051296133 cites W2050831370 @default.
• W2051296133 cites W2052411722 @default.
• W2051296133 cites W2056886854 @default.
• W2051296133 cites W2058825620 @default.
• W2051296133 cites W2059809438 @default.
• W2051296133 cites W2061352595 @default.
• W2051296133 cites W2062581776 @default.
• W2051296133 cites W2066269914 @default.
• W2051296133 cites W2073785345 @default.
• W2051296133 cites W2076538267 @default.
• W2051296133 cites W2081246637 @default.
• W2051296133 cites W2081788499 @default.
• W2051296133 cites W2082928585 @default.
• W2051296133 cites W2083847100 @default.
• W2051296133 cites W2085583092 @default.
• W2051296133 cites W2085722593 @default.
• W2051296133 cites W2095603321 @default.
• W2051296133 cites W2096119021 @default.
• W2051296133 cites W2097382368 @default.
• W2051296133 cites W2098697457 @default.
• W2051296133 cites W2102428328 @default.
• W2051296133 cites W2102453705 @default.
• W2051296133 cites W2105845246 @default.
• W2051296133 cites W2110036277 @default.
• W2051296133 cites W2110335151 @default.
• W2051296133 cites W2111150414 @default.

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