FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051296170> ?p ?o ?g. }

• W2051296170 endingPage "142" @default.
• W2051296170 startingPage "135" @default.
• W2051296170 abstract "We have investigated changes in the morphological structure of Abeta1-40 during different incubation time periods at 37 degrees C ranging from 1 h to 7 days using Thioflavin T, Congo red binding and electron microscopy. We found distinctive changes in Abeta assembly demonstrating the formation of beta pleated sheets following 7-day incubation. Here we demonstrate that samples of the same Abeta1-40 peptide that are morphologically distinct can both attenuate hippocampal long-term potentiation (LTP) in the CA1 in vivo. The peptides were applied via intracerebroventricular injection and the effects on synaptic transmission, post-tetanic potentiation (PTP) and LTP were observed. The effects of Abeta1-40 that had either been freshly solubilized (FS-Abeta) or incubated at 37 degrees C for 7 days (7D-Abeta) were examined. FS-Abeta and 7D-Abeta peptide were both found to significantly attenuate LTP, although the assembly states of these peptides appeared to be completely different. Paired pulse facilitation (PPF) with an inter-stimulus interval of 50 ms was also monitored prior to, following peptide injection and 60 min following LTP induction. 7D-Abeta caused an increase in PPF prior to LTP induction and also depressed PTP. Our data demonstrate that, while both forms of the peptide can attenuate LTP, the fibrillar form of the peptide may also influence transmitter release." @default.
• W2051296170 created "2016-06-24" @default.
• W2051296170 creator A5021004185 @default.
• W2051296170 creator A5038444229 @default.
• W2051296170 creator A5069537611 @default.
• W2051296170 date "2008-03-01" @default.
• W2051296170 modified "2023-10-14" @default.
• W2051296170 title "Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states" @default.
• W2051296170 cites W1569515633 @default.
• W2051296170 cites W1572178618 @default.
• W2051296170 cites W1762207349 @default.
• W2051296170 cites W1913141297 @default.
• W2051296170 cites W1915192275 @default.
• W2051296170 cites W1969579852 @default.
• W2051296170 cites W1972850054 @default.
• W2051296170 cites W1980767889 @default.
• W2051296170 cites W1981570625 @default.
• W2051296170 cites W1986559032 @default.
• W2051296170 cites W2001900724 @default.
• W2051296170 cites W2004968757 @default.
• W2051296170 cites W2014174528 @default.
• W2051296170 cites W2019644389 @default.
• W2051296170 cites W2021235911 @default.
• W2051296170 cites W2023354655 @default.
• W2051296170 cites W2024080895 @default.
• W2051296170 cites W2029898162 @default.
• W2051296170 cites W2030452219 @default.
• W2051296170 cites W2030808787 @default.
• W2051296170 cites W2031785254 @default.
• W2051296170 cites W2037392168 @default.
• W2051296170 cites W2046349516 @default.
• W2051296170 cites W2046974636 @default.
• W2051296170 cites W2056126207 @default.
• W2051296170 cites W2059545089 @default.
• W2051296170 cites W2059878016 @default.
• W2051296170 cites W2071953900 @default.
• W2051296170 cites W2073516240 @default.
• W2051296170 cites W2073766297 @default.
• W2051296170 cites W2082501707 @default.
• W2051296170 cites W2087969945 @default.
• W2051296170 cites W2109818484 @default.
• W2051296170 cites W2121716072 @default.
• W2051296170 cites W2121897932 @default.
• W2051296170 cites W2122357222 @default.
• W2051296170 cites W2123321976 @default.
• W2051296170 cites W2126218225 @default.
• W2051296170 cites W2127265740 @default.
• W2051296170 cites W2129412868 @default.
• W2051296170 cites W2132573038 @default.
• W2051296170 cites W2133518054 @default.
• W2051296170 cites W2136901555 @default.
• W2051296170 cites W2142692094 @default.
• W2051296170 cites W2145904082 @default.
• W2051296170 cites W2150999725 @default.
• W2051296170 cites W2152044871 @default.
• W2051296170 cites W2152278845 @default.
• W2051296170 doi "https://doi.org/10.1016/j.brainres.2007.11.056" @default.
• W2051296170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18237717" @default.
• W2051296170 hasPublicationYear "2008" @default.
• W2051296170 type Work @default.
• W2051296170 sameAs 2051296170 @default.
• W2051296170 citedByCount "27" @default.
• W2051296170 countsByYear W20512961702012 @default.
• W2051296170 countsByYear W20512961702013 @default.
• W2051296170 countsByYear W20512961702014 @default.
• W2051296170 countsByYear W20512961702015 @default.
• W2051296170 countsByYear W20512961702017 @default.
• W2051296170 countsByYear W20512961702018 @default.
• W2051296170 countsByYear W20512961702019 @default.
• W2051296170 countsByYear W20512961702020 @default.
• W2051296170 countsByYear W20512961702021 @default.
• W2051296170 countsByYear W20512961702022 @default.
• W2051296170 countsByYear W20512961702023 @default.
• W2051296170 crossrefType "journal-article" @default.
• W2051296170 hasAuthorship W2051296170A5021004185 @default.
• W2051296170 hasAuthorship W2051296170A5038444229 @default.
• W2051296170 hasAuthorship W2051296170A5069537611 @default.
• W2051296170 hasConcept C12554922 @default.
• W2051296170 hasConcept C126322002 @default.
• W2051296170 hasConcept C134018914 @default.
• W2051296170 hasConcept C148762608 @default.
• W2051296170 hasConcept C150903083 @default.
• W2051296170 hasConcept C170493617 @default.
• W2051296170 hasConcept C185592680 @default.
• W2051296170 hasConcept C200170125 @default.
• W2051296170 hasConcept C207001950 @default.
• W2051296170 hasConcept C25274449 @default.
• W2051296170 hasConcept C2776328245 @default.
• W2051296170 hasConcept C2778896982 @default.
• W2051296170 hasConcept C2779134260 @default.
• W2051296170 hasConcept C2779281246 @default.
• W2051296170 hasConcept C29561615 @default.
• W2051296170 hasConcept C502032728 @default.
• W2051296170 hasConcept C55493867 @default.
• W2051296170 hasConcept C71924100 @default.
• W2051296170 hasConcept C86803240 @default.
• W2051296170 hasConceptScore W2051296170C12554922 @default.
• W2051296170 hasConceptScore W2051296170C126322002 @default.

• next