Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051297694> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2051297694 abstract "Abstract We have recently characterized a novel angiotensin II/vasopressin (Ang II/AVP) dual receptor coupled to adenylate cyclase and responding with equal sensitivity to Ang II and AVP. To gain insight into putative renal physiological roles of the dual Ang II/AVP receptor, we determined its pharmacological binding properties and renal immunocytochemical distribution. The effective displacement of [ 3 H]AVP by [1-deamino-Val 14 , d -Arg 8 ]-vasopressin (DVDAVP), a specific antidiuretic AVP analogue, supports a V 2 -type AVP receptor characteristic of the Ang II/AVP receptor. Displacement of 125 I–Ang II by losartan but not by PD 123319 defines the Ang II/AVP receptor as a novel AT 1 receptor isoform coupled to adenylate cyclase, in contrast to prototype Ca 2+ -mobilizing AT 1 receptors. Neither Ang II nor AVP displace each other, corroborating the predicted discrete binding domains for Ang II and AVP but presenting an enigma for the dissection of putative Ang II–and AVP-specific hierarchical roles of the dual Ang II/AVP receptor. The renal cytolocalization of the Ang II/AVP receptor to the outer medullary thick ascending limb tubules and inner medullary collecting ducts is consistent with the well-established AVP stimulation of sodium and water reabsorption in these tubules. These data suggest that the Ang II/AVP receptor might provide the molecular basis for the observed similar stimulatory effects of Ang II and AVP on renal tubular sodium and fluid reabsorption at physiological hormone concentrations." @default.
- W2051297694 created "2016-06-24" @default.
- W2051297694 creator A5032252749 @default.
- W2051297694 creator A5039919795 @default.
- W2051297694 creator A5066616713 @default.
- W2051297694 date "1997-04-01" @default.
- W2051297694 modified "2023-09-25" @default.
- W2051297694 title "Renal Immunocytochemical Distribution and Pharmacological Properties of the Dual Angiotensin II/AVP Receptor" @default.
- W2051297694 cites W1013606601 @default.
- W2051297694 cites W1527240164 @default.
- W2051297694 cites W1549512600 @default.
- W2051297694 cites W1558224624 @default.
- W2051297694 cites W1869816397 @default.
- W2051297694 cites W1963537641 @default.
- W2051297694 cites W1964640948 @default.
- W2051297694 cites W1967561584 @default.
- W2051297694 cites W1968874083 @default.
- W2051297694 cites W1970911947 @default.
- W2051297694 cites W1990257506 @default.
- W2051297694 cites W1996996770 @default.
- W2051297694 cites W200316056 @default.
- W2051297694 cites W2026338227 @default.
- W2051297694 cites W2028966950 @default.
- W2051297694 cites W2045520532 @default.
- W2051297694 cites W2058713776 @default.
- W2051297694 cites W2078118683 @default.
- W2051297694 cites W2082542825 @default.
- W2051297694 cites W2094261260 @default.
- W2051297694 cites W2113086555 @default.
- W2051297694 cites W2131706912 @default.
- W2051297694 cites W2150429633 @default.
- W2051297694 cites W2398647414 @default.
- W2051297694 cites W397833519 @default.
- W2051297694 cites W4250860433 @default.
- W2051297694 cites W4253966289 @default.
- W2051297694 doi "https://doi.org/10.1161/01.hyp.29.4.957" @default.
- W2051297694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9095083" @default.
- W2051297694 hasPublicationYear "1997" @default.
- W2051297694 type Work @default.
- W2051297694 sameAs 2051297694 @default.
- W2051297694 citedByCount "19" @default.
- W2051297694 countsByYear W20512976942012 @default.
- W2051297694 countsByYear W20512976942015 @default.
- W2051297694 countsByYear W20512976942018 @default.
- W2051297694 crossrefType "journal-article" @default.
- W2051297694 hasAuthorship W2051297694A5032252749 @default.
- W2051297694 hasAuthorship W2051297694A5039919795 @default.
- W2051297694 hasAuthorship W2051297694A5066616713 @default.
- W2051297694 hasConcept C104849204 @default.
- W2051297694 hasConcept C126322002 @default.
- W2051297694 hasConcept C134018914 @default.
- W2051297694 hasConcept C170493617 @default.
- W2051297694 hasConcept C185592680 @default.
- W2051297694 hasConcept C20352681 @default.
- W2051297694 hasConcept C2776370428 @default.
- W2051297694 hasConcept C2776885963 @default.
- W2051297694 hasConcept C2780091579 @default.
- W2051297694 hasConcept C2780288358 @default.
- W2051297694 hasConcept C2908929049 @default.
- W2051297694 hasConcept C56906281 @default.
- W2051297694 hasConcept C57476199 @default.
- W2051297694 hasConcept C71924100 @default.
- W2051297694 hasConcept C86803240 @default.
- W2051297694 hasConcept C90474776 @default.
- W2051297694 hasConceptScore W2051297694C104849204 @default.
- W2051297694 hasConceptScore W2051297694C126322002 @default.
- W2051297694 hasConceptScore W2051297694C134018914 @default.
- W2051297694 hasConceptScore W2051297694C170493617 @default.
- W2051297694 hasConceptScore W2051297694C185592680 @default.
- W2051297694 hasConceptScore W2051297694C20352681 @default.
- W2051297694 hasConceptScore W2051297694C2776370428 @default.
- W2051297694 hasConceptScore W2051297694C2776885963 @default.
- W2051297694 hasConceptScore W2051297694C2780091579 @default.
- W2051297694 hasConceptScore W2051297694C2780288358 @default.
- W2051297694 hasConceptScore W2051297694C2908929049 @default.
- W2051297694 hasConceptScore W2051297694C56906281 @default.
- W2051297694 hasConceptScore W2051297694C57476199 @default.
- W2051297694 hasConceptScore W2051297694C71924100 @default.
- W2051297694 hasConceptScore W2051297694C86803240 @default.
- W2051297694 hasConceptScore W2051297694C90474776 @default.
- W2051297694 hasLocation W20512976941 @default.
- W2051297694 hasLocation W20512976942 @default.
- W2051297694 hasOpenAccess W2051297694 @default.
- W2051297694 hasPrimaryLocation W20512976941 @default.
- W2051297694 hasRelatedWork W1966699539 @default.
- W2051297694 hasRelatedWork W1996846474 @default.
- W2051297694 hasRelatedWork W2007102871 @default.
- W2051297694 hasRelatedWork W2048334412 @default.
- W2051297694 hasRelatedWork W2051297694 @default.
- W2051297694 hasRelatedWork W2062690991 @default.
- W2051297694 hasRelatedWork W2069855804 @default.
- W2051297694 hasRelatedWork W2070539845 @default.
- W2051297694 hasRelatedWork W2281410802 @default.
- W2051297694 hasRelatedWork W1996764561 @default.
- W2051297694 isParatext "false" @default.
- W2051297694 isRetracted "false" @default.
- W2051297694 magId "2051297694" @default.
- W2051297694 workType "article" @default.