FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051298343> ?p ?o ?g. }

• W2051298343 endingPage "1645" @default.
• W2051298343 startingPage "1637" @default.
• W2051298343 abstract "In IL-2-deficient mice, antigen-activated CD4 T cells accumulate and cause lethal immune pathology. Wild-type cells of hematopoietic origin present in the same animal are able to prevent this hyperactivation of T cells, but the mechanisms and cells controlling the IL-2-deficient cells are unknown. Here we show that IL-2(-) CD4 cells with an ovalbumin-specific transgenic TCR (IL-2(-) OVAtg) undergo both clonal expansion and clonal contraction when transferred to euthymic recipients and challenged with antigen, but continuously expand in athymic hosts. Cotransfer of wild-type CD4 T cells prevents the accumulation of IL-2-deficient cells. On the residual IL-2(-) TCRtg cells CD69 and CD25 are up-regulated, suggesting that activation per se is not suppressed and that the cells had received an IL-2 signal. Since IL-2 is able to restore the defective antigen-induced cell death (AICD) of IL-2-deficient T cells in vitro, paracrine IL-2 provided by the wild-type CD4 cells may thus be able to allow clonal contraction of IL-2-deficient cells also in vivo. Interestingly however, regulatory CD4(+)CD25(+) cells also efficiently contain the clone size of antigen-stimulated IL-2-deficient T cells. Since CD4(+)CD25(+) cells do not produce IL-2, this suggests a mechanism of suppression distinct from paracrine IL-2 delivery. In keeping with this, the residual IL-2(-) TCRtg cells recovered after cotransfer of regulatory CD4(+)CD25(+) cells do not show increased CD25 or CD69 expression, suggesting that they had not received paracrine IL-2 and that clonal containment occurred at the level of initial activation rather than clonal contraction by AICD. IL-2 deficiency therefore may upset T cell homeostasis by two distinct mechanisms: the failure to program expanding T cells for apoptosis, and the failure to generate functional CD4(+)CD25(+) regulatory cells." @default.
• W2051298343 created "2016-06-24" @default.
• W2051298343 creator A5079539654 @default.
• W2051298343 creator A5079775941 @default.
• W2051298343 creator A5089689630 @default.
• W2051298343 date "2001-06-01" @default.
• W2051298343 modified "2023-10-01" @default.
• W2051298343 title "Control of T cell hyperactivation in IL-2-deficient mice by CD4+CD25- and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms" @default.
• W2051298343 cites W1516581843 @default.
• W2051298343 cites W1974351164 @default.
• W2051298343 cites W1982051091 @default.
• W2051298343 cites W1993051112 @default.
• W2051298343 cites W2000208875 @default.
• W2051298343 cites W2029411077 @default.
• W2051298343 cites W2036160208 @default.
• W2051298343 cites W2039047676 @default.
• W2051298343 cites W2043587802 @default.
• W2051298343 cites W2044163622 @default.
• W2051298343 cites W2045008512 @default.
• W2051298343 cites W2045108569 @default.
• W2051298343 cites W2055669282 @default.
• W2051298343 cites W2057300885 @default.
• W2051298343 cites W2066300320 @default.
• W2051298343 cites W2067945089 @default.
• W2051298343 cites W2079135245 @default.
• W2051298343 cites W2079721061 @default.
• W2051298343 cites W2101230909 @default.
• W2051298343 cites W2102448121 @default.
• W2051298343 cites W2107862038 @default.
• W2051298343 cites W2114866206 @default.
• W2051298343 cites W2114885573 @default.
• W2051298343 cites W2115277104 @default.
• W2051298343 cites W2135245523 @default.
• W2051298343 cites W2137560059 @default.
• W2051298343 cites W2139191751 @default.
• W2051298343 cites W2144320908 @default.
• W2051298343 cites W2148781892 @default.
• W2051298343 cites W2154224978 @default.
• W2051298343 cites W2159987448 @default.
• W2051298343 cites W2168879228 @default.
• W2051298343 cites W4313324526 @default.
• W2051298343 doi "https://doi.org/10.1002/1521-4141(200106)31:6<1637::aid-immu1637>3.0.co;2-t" @default.
• W2051298343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11385607" @default.
• W2051298343 hasPublicationYear "2001" @default.
• W2051298343 type Work @default.
• W2051298343 sameAs 2051298343 @default.
• W2051298343 citedByCount "178" @default.
• W2051298343 countsByYear W20512983432012 @default.
• W2051298343 countsByYear W20512983432013 @default.
• W2051298343 countsByYear W20512983432014 @default.
• W2051298343 countsByYear W20512983432015 @default.
• W2051298343 countsByYear W20512983432016 @default.
• W2051298343 countsByYear W20512983432017 @default.
• W2051298343 countsByYear W20512983432018 @default.
• W2051298343 countsByYear W20512983432019 @default.
• W2051298343 countsByYear W20512983432020 @default.
• W2051298343 countsByYear W20512983432021 @default.
• W2051298343 countsByYear W20512983432022 @default.
• W2051298343 countsByYear W20512983432023 @default.
• W2051298343 crossrefType "journal-article" @default.
• W2051298343 hasAuthorship W2051298343A5079539654 @default.
• W2051298343 hasAuthorship W2051298343A5079775941 @default.
• W2051298343 hasAuthorship W2051298343A5089689630 @default.
• W2051298343 hasConcept C129374314 @default.
• W2051298343 hasConcept C131665280 @default.
• W2051298343 hasConcept C147483822 @default.
• W2051298343 hasConcept C153911025 @default.
• W2051298343 hasConcept C170493617 @default.
• W2051298343 hasConcept C203014093 @default.
• W2051298343 hasConcept C2776090121 @default.
• W2051298343 hasConcept C55493867 @default.
• W2051298343 hasConcept C67662055 @default.
• W2051298343 hasConcept C7876069 @default.
• W2051298343 hasConcept C79484868 @default.
• W2051298343 hasConcept C86803240 @default.
• W2051298343 hasConcept C8891405 @default.
• W2051298343 hasConcept C95444343 @default.
• W2051298343 hasConceptScore W2051298343C129374314 @default.
• W2051298343 hasConceptScore W2051298343C131665280 @default.
• W2051298343 hasConceptScore W2051298343C147483822 @default.
• W2051298343 hasConceptScore W2051298343C153911025 @default.
• W2051298343 hasConceptScore W2051298343C170493617 @default.
• W2051298343 hasConceptScore W2051298343C203014093 @default.
• W2051298343 hasConceptScore W2051298343C2776090121 @default.
• W2051298343 hasConceptScore W2051298343C55493867 @default.
• W2051298343 hasConceptScore W2051298343C67662055 @default.
• W2051298343 hasConceptScore W2051298343C7876069 @default.
• W2051298343 hasConceptScore W2051298343C79484868 @default.
• W2051298343 hasConceptScore W2051298343C86803240 @default.
• W2051298343 hasConceptScore W2051298343C8891405 @default.
• W2051298343 hasConceptScore W2051298343C95444343 @default.
• W2051298343 hasIssue "6" @default.
• W2051298343 hasLocation W20512983431 @default.
• W2051298343 hasLocation W20512983432 @default.
• W2051298343 hasOpenAccess W2051298343 @default.
• W2051298343 hasPrimaryLocation W20512983431 @default.
• W2051298343 hasRelatedWork W1483299903 @default.
• W2051298343 hasRelatedWork W1502196931 @default.

• next